Jaguars (2-2) at Bills (3-1)

Sunday, 9:30 a.m. EDT, Tottenham Hotspur Stadium, London

TV: NFL Network

Spread (BetMGM):

Bills by 5.5

Jaguars’ keys to victory: The Bills are fresh off three straight blowout wins. Even so, Buffalo’s season-opening loss to the Jets was not long ago. The Jaguars have to take a page out of the Jets’ book and get in the face of Bills QB Josh Allen. The Jets sacked Allen five times and hit him nine total times in Week 1. That led to drives stalling and Allen turning the ball over four times. Generating consistent pressure will get QB Trevor Lawrence back on the field. The Jaguars kept the ball for five more minutes than Atlanta in a Week 4 London win.

Bills’ keys to victory: There aren’t going to be any secondaries that scare the Bills and Allen after the way things have gone for theme recently. WR Stefon Diggs looked unstoppable when he had three touchdowns against the Dolphins in Week 4. But running the ball will be important against Jacksonville. Jacksonville has a promising secondary with Tyson Campbell, Tre Herndon and Darious Williams. Buffalo is going to take its shots, and if RB James Cook makes the Jags defense respect the ground game, that will open it up for Allen and Diggs.

Matchup to watch: Jaguars WR Christian Kirk vs. Bills CB Christian Benford. It’s going to be the Bills’ first game without No. 1 CB Tre’Davious White (Achilles tendon injury). Is Benford ready to be the top corner?

Who wins? While the Jags have managed to squeak out wins as of late, the Bills have outscored opponents 123-33 over the past three weeks.

Bills 34-21

Nick Wojton, Bills Wire