ARIZONA CARDINALS (4-0) AT ST. LOUIS RAMS (2-2)

8:20 p.m. ET, NFL Network, Brad Nessler, Mike Mayock, Alex Flanagan Covers. com line: Cardinals by 1 uLast meeting: Arizona won in St. Louis 23-20 on Nov. 27 last season by scoring 17 unanswered points in the third quarter.

Streaking: The Rams have lost seven consecutive home games to the Cardinals.

Respect the Rams D: Opposing quarterbacks have posted a 64.2 passer rating against St. Louis. That gives the Rams the best mark in the NFL and is a testament to the improvement CBs Cortland Finnegan and rookie Janoris Jenkins have provided.

Arizona surrendered eight sacks last weekend vs. the Miami Dolphins. Struggling Ts D’Anthony Batiste and Bobby Massie will have to contend with formidable DEs Robert Quinn and Chris Long. The Cardinals also need RB Ryan Williams to step up and at least provide the threat of a running game to slow the pass rush.

QB Kevin Kolb did an admirable job in the face of constant pressure against the Dolphins, but he also threw two interceptions. Digging out of another early hole would be far more difficult on the road.

Building a blueprint: The Cardinals are building a vaunted defense, but the Rams certainly found time despite a short week to study film of Dolphins rookie QB Ryan Tannehill racking up 431 passing yards last weekend despite marginal help from his ground game.

St. Louis wants to spread the ball around the field to help create running lanes for RB Steven Jackson. WR Danny Amendola continues to be QB Sam Bradford’s safety net for moving the chains.

Bradford hasn’t stretched the field often, but look for him to test RCB William Gay working against WRs Brandon Gibson and Brian Quick.

Need to know: Cardinals WR Andre Roberts has four touchdown catches through four games. He entered the season with four through his first two seasons. . . . Rams cornerbacks have six interceptions, one more than the team’s corners produced in all of 2011.