THURSDAY NIGHT GAME Broncos (2-4) at Cardinals (1-5)

Time, TV: 8:20 p.m. ET Thursday; Fox, NFL Network, Amazon

Pregame.com line: Broncos by 11⁄ 2

Broncos’ keys: Denver depends on its defense, and it can again against a struggling Cardinals offense. It needs to limit RB David Johnson, keep Arizona from converting on third down and run the ball effectively itself. Cardinals’ keys: Arizona must create turnovers, as it has in its last two games, and must limit the Denver rushing attack, something that has been very tough for all opponents.

Who wins? A return home brings out a good game from Arizona rookie QB Josh Rosen, but the Cardinals again will struggle to run the ball and will not be able to stop the Denver rushing attack. Broncos, 20-17