Wellness Update - - News -

--Re­searchers at The Tisch Can­cer In­sti­tute at the Ic­ahn School of Medicine at Mount Si­nai have dis­cov­ered a key mech­a­nism by which ra­di­a­tion treat­ment (ra­dio­ther­apy) fails to com­pletely de­stroy tu­mors. And, in the jour­nal Na­ture Im­munol­ogy, they of­fer a novel so­lu­tion to pro­mote suc­cess­ful ra­dio­ther­apy for the mil­lions of can­cer pa­tients who are treated with it. The team found that when ra­dio­ther­apy dam­ages skin har­bor­ing tu­mors, spe­cial skin im­mune cells called Langer­hans cells are ac­ti­vated. Th­ese Langer­hans cells can uniquely re­pair the dam­age in their own DNA caused by ra­dio­ther­apy, al­low­ing them to be­come re­sis­tant to ra­dio­ther­apy and to even trig­ger an im­mune re­sponse caus­ing skin tu­mors such as melanoma, to re­sist fur­ther treat­ment In­ves­ti­ga­tors mim­icked the ef­fect of im­munother­apy drugs called “im­mune check­point in­hibitors” to boost the im­mune sys­tem to at­tack tu­mors. This in turn blocked the abil­ity of Langer­hans cells to re­pair their own DNA af­ter ra­dio­ther­apy caus­ing them to die, pre­vent­ing an im­mune re­sponse that pro­tects skin tu­mors. “Our study sug­gests that this com­bi­na­tion ap­proach — com­bin­ing ra­dio­ther­apy with drugs that rev up a healthy im­mune re­sponse — will help make ra­di­a­tion ther­apy much more ef­fec­tive,” says the study’s lead au­thor, im­mu­nol­o­gist Jeremy Price, PhD.


-- Di­ets high in meat may lead to an in­creased risk of de­vel­op­ing re­nal cell car­ci­noma (RCC) through in­take of car­cino­genic com­pounds cre­ated by cer­tain cook­ing tech­niques, such as bar­be­cu­ing and pan-fry­ing. As part of a new study from The Univer­sity of Texas MD An­der­son Can­cer Cen­ter, re­searchers also dis­cov­ered that in­di­vid­u­als with spe­cific ge­netic mu­ta­tions are more sus­cep­ti­ble to the harm­ful com­pounds cre­ated when cook­ing at high tem­per­a­tures. Re­nal cell car­ci­noma, the most com­mon form of kid­ney can­cer, is ex­pected to be di­ag­nosed in over 60,000 new pa­tients this year and claim ap­prox­i­mately 14,000 lives, ac­cord­ing to the Amer­i­can Can­cer So­ci­ety. The in­ci­dence of RCC has been ris­ing for sev­eral decades, and many sug­gest that a Western diet is par­tially, to blame. One of the pro­posed cul­prits of a Western diet is high­erthan-av­er­age meat consumption, which has been linked

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