T-Virus Resident Evil
The most famous contagion in gaming history takes the number two spot with its classic take on a zombie-like disease. It’s not just one strain, there are several variations of it and, despite Umbrella collapsing from the scandal of thousands of needless deaths, other companies are determined to weaponise it. Sounds smart. Once you’re exposed it takes several days for the virus to reach its final stages and during that period you get to be painfully aware of how your own mind is deteriorating while your skin rots and your bodily functions shut down. Technically you’re not even dead, your body is very much alive, you just don’t have the capacity for thought any more.