Get the tone

Brian May has one of those truly unique guitar tones; a combination of coin instead of pick and his famous Red Special through Vox AC30s. A bridge humbucker with the amp’s mid-range boosted and a healthy dollop of drive will get you reasonably close, however. As well as plenty of mid-range, you might also like to push your hi-eq (on either amp or pedal) to get some of the brittleness that exists in Brian’s sound.