New Contraindications
Colifoam Rectal Foam (hydrocortisone acetate) is now contraindicated with tuberculous or other infections, obstruction, abscess, perforation, peritonitis, fresh intestinal anastomoses, extensive fistulae.
Evotaz (atazanavir sulfate/cobicistat) and Reyataz (atazanavir sulfate) should not be used in combination with elbasvir/grazoprevir because of the potential increase in the risk of ALT elevations due to a significant increase in grazoprevir plasma concentrations caused by OATP1B1/3 inhibition.
Merieux Inactivated Rabies Vaccine (inactivated rabies vaccine) pre-exposure vaccination must be postponed in case of febrile or acute disease. Since rabies infection generally results in death, there are no contraindications to post-exposure vaccination.
Sporanox Capsules (itraconazole) and Sporanox Oral Solution (itraconazole) are now contraindicated in combination with isavuconazole, naloxegol, lomitapide, avanafil, dapoxetine or eliglustat.
Tarka (trandolapril/verapamil) is now contraindicated in combination with neprilysin (neutral endopeptidase, NEP) inhibitors such as sacubitril and racedotril.
This list is a summary of only some of the changes that have occurred over the last month. Before prescribing, always refer to the full product information.