New Contraindications
Gopten (trandolapril) is now contraindicated with concomitant neprilysin (neutral endopeptidase, NEP) inhibitors such as sacubitril and racecadotril.
Priorix (measles, mumps and rubella vaccine (live, attenuated)) and Priorix-Tetra (measles, mumps, rubella and varicella vaccine (live, attenuated)) are now contraindicated in patients with severe humoral or cellular (primary or acquired) immunodeficiency, e.g. symptomatic HIV infection.
Coadministration of Stribild (tenofovir disoproxil fumarate/emtricitabine/elvitegravir/cobicistat) is now contraindicated with drugs that are highly dependent on CYP3A for clearance and for which elevated plasma concentrations are associated with serious and/or life-threatening events, and with drugs that are potent inducers of CYP3A due to the potential for loss of virologic response and possible resistance to Stribild.
Coadministration of Viekira Pak (paritaprevir/ritonavir/ombitasvir/dasabuvir) and Viekira Pak-RBV (paritaprevir/ritonavir/ombitasvir/dasabuvir/ribavirin) with atorvastatin is now contraindicated due to the potential for myopathy including rhabdomyolysis.
This list is a summary of only some of the changes that have occurred over the last month. Before prescribing, always refer to the full product information.