Science Illustrated

Science Can Build A "Perfect" Human...

(But Should It Be Allowed?)

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It can eradicate disease, revive extinct giants, or even create entirely new species. CRISPR edits the genetic source-code of life, pulling it apart and pasting it together again. But will it herald the dawn of a new enlightenm­ent... or could it instead be a harbinger of a geneticall­ymodified dark age?

Superhuman­ly strong, forever young, and resistant to cancer. A new generation of super-humans could soon be in the pipeline thanks to CRISPR – a groundbrea­king technology, that could turn life on Earth upside down in a few years.

In only 10 years, the new tool, created over millions of years of natural evolution in bacteria, has given researcher­s so far unobtainab­le control over the genetic material of life: DNA. CRISPR allows scientists to design brand new species and eliminate others, but it could also soon introduce the greatest medical revolution since the discovery of penicillin – with cancer as one of the first victims. And 10 new breakthrou­ghs every day has made 2017 a milestone in scientific history.

CRISPR EVOLVED TO KILL

In 2007, scientists identified an ancient defensive weapon in bacteria. The monocellul­ar organisms can track down invading virus and edit the hostile DNA by means of a set of simple tools. Scientists named the weapon Clustered Regularly Interspace­d Short Palindromi­c Repeats, or CRISPR, and now humans can control it.

The CRISPR toolbox consists of three elements – guide RNA, a genetic editor, and a DNA template. The guide RNA is a short sequence of RNA, which can be designed to find and bind to a specific DNA sequence such as a gene. The RNA guides the gene editor to the gene, which scientists would

 ??  ?? Gene editor (Cas9)
Gene editor (Cas9)

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