Scientists develop microrobot for precision medicine
HARBIN: Chinese scientists have developed a swimming microrobot complete with claws and a coat that mimics the red blood cell membrane, significantly improving the efficiency of targeted drug delivery in blood vessels, Xinhua News Agency reported.
The magnetic robot is 20 microns in diameter and has claws inspired by tardigrades, a kind of tiny invertebrate. This allows for beter navigation through the veins and shows promise for precision medicine, according to the paper published in the journal Science Advances.
Swimming microrobots offer promising possibilities for delivering drugs to body tissues that are hard to reach, while addressing problems such as intensive blood flow and a limited ability to stick to the target sites in blood vessels.
Researchers from the Harbin Institute of Technology (HIT), in collaboration with their counterparts at the First Affiliated Hospital of Harbin Medical University, took inspiration from tardigrades, whose claws can grip plants in water, enabling them to survive in fast-flowing liquid.
The clawed microrobot has an outer layer disguised as a red blood cell membrane, which improves its adhesion to the inner wall of the vessels.
The researchers monitored the robot’s activity and dynamics in a rabbit vein and observed very effective magnetic propulsion even at a high flow rate, said the paper.
The findings bring a new insight into the precision medicine, such as treating malignant tumors, by significantly improving the efficiency of targeted drug delivery, according to HIT.
Separately, a new study revealed that people with genetic tendency towards higher levels of hypertension and cholesterol could be at a potential risk of developing Alzheimer’s disease, according to a new study.
The study, published in the journal JAMA Network Open, included 39,106 people with clinically diagnosed Alzheimer’s and 401,577 controls who did not have the disease.
The team from Copenhagen University in
Denmark found that people who had certain genes that led to higher levels of a type of cholesterol called high-density lipoprotein, also known as HDL or “good” cholesterol, had a slightly higher chance of developing Alzheimer’s.
For every standard deviation increase in HDL cholesterol, the researchers found about 10 per cent increase in the risk of Alzheimer’s.
A similar increased risk was found for people with the genes responsible for higher systolic blood pressure. For every 10 millimetres of mercury (mm Hg) increase in systolic blood pressure, the risk of developing Alzheimer’s increased 1.22 times.