Immuno drugs darken cancer patients’ grey hair

Cancer patients’ grey hair unexpectedly turned youthfully dark while taking novel drugs, and it has doctors scratching their heads.

Chemotherapy is notorious for making hair fall out, but the 14 patients involved were all being treated with new immunotherapy drugs that work differently and have different side effects. A Spanish study suggests that may include restoring hair pigment, at least in patients with lung cancer.

With the first patient, “we thought it could be an isolated case,” said Dr. Noelia Rivera, a dermatologist at Autonomous University of Barcelona.

But she said the research team found the same thing when they asked other patients for photos from before treatment.

The 14 cases were among 52 lung cancer patients being followed to see whether they developed bad side-effects from the drugs — Keytruda, Opdivo and Tecentriq.

While most patients did not have a colour change, the 14 cases suggest it’s not an isolated finding. In 13 patients, hair turned darkish brown or black. In one patient, it turned black in patches.

In another odd twist, the same drugs have been linked previously with hair losing colour in patients with another cancer, melanoma.

All but one of the 14 patients in the Spanish study had at least stable disease and responded better to treatment than other patients, suggesting that hair darkening might be an indication that the drugs are working, the researchers said.

Rivera said they are continuing the study to search for an explanation and to see if the cases are just a fluke.

JAMA via Associated Press This undated combination of photos provided by the Journal of the American Medical Association shows a cancer patient with grey hair that unexpectedly turned dark while the patient was taking new immunotherapy drugs.