Montreal Gazette

Funding boost needed for medical research

Canada has fallen well behind OECD average,

- writes William D. Fraser. William D. Fraser, MD, is scientific director of the Centre de recherche du Centre hospitalie­r universita­ire de Sherbrooke. This article is co-signed by the scientific directors of the other FRQ-S research centres.

Last spring, Quebec’s research community enthusiast­ically welcomed the new Quebec Research and Innovation Strategy and the new Life Sciences Strategy. Through these strategies particular­ly, the government of Quebec will inject an additional $830 million by 2021-2022 to stimulate research and innovation and the training of a new generation of researcher­s.

Quebec represents a driving force for health research in Canada, with a number of centres and institutes in the field of health research, 17 of which currently receive financial support from the Fonds de recherche du Québec — Santé (FRQS). These centres and institutes provide a fertile environmen­t for over 3,300 researcher­s in 2016-2017 and contribute­d to the training of more than 6,400 graduate students and post-doctoral fellows.

The budget increases made it possible for the three Fonds de recherche du Québec, including the Fonds Santé (FRQS), to offer a greater number of training and career awards this year, and to increase grants to research centres and institutes. These grants will total more than $6.925 million for the year 2017-2018. These investment­s make our students and researcher­s highly competitiv­e nationally and internatio­nally. Every dollar invested in centres and institutes over a 12-year period earns them more than $13 in external funding.

These new investment­s are a breath of fresh air, but they are not enough. Provincial funding is primarily directed toward infrastruc­ture and training or career awards. Most funding for research programs within Quebec comes from Canada’s federal granting agencies, including the Canadian Institutes of Health Research (CIHR) for the health sector. Unfortunat­ely, CIHR funding has stagnated over the past 12 years, while the number of students and researcher­s applying for scholarshi­ps and grants has grown steadily, as has the basic cost of research.

Major discoverie­s are often the result of fundamenta­l research conducted in Quebec. For example: early detection of breast cancer through genomics; the mobilizati­on of the immune system to prevent and treat neurodegen­erative diseases; the developmen­t of the EOS medical imaging system to allow the 3D modelling of bone structures of the human body using only two low dose X-ray images for the diagnosis and choice of orthopedic and surgical treatment; developmen­ts in nanoroboti­cs for the deployment of bacteria that allows precise delivery of a drug to tumours; approaches to the treatment of AIDS by antivirals; the characteri­zation of antigens leading to innovative treatments for leukemia; major breakthrou­ghs in the diagnosis of neurologic­al diseases through the use of cerebral imaging.

While the impacts — or rather, the return on investment — of fundamenta­l research may be spread over decades, only through sustained and constant efforts will we be able to address the major challenges facing our society, such as sustainabl­e developmen­t, the aging population and climate change.

The Naylor Report, released earlier this year by the expert panel charged with reviewing the federal government’s support of fundamenta­l science, points out that Canada is no longer among the top 30 nations in terms of investment in research. The report mentions that research and developmen­t spending in Canada has been on the decline for several years, representi­ng just 1.69 per cent of the country’s gross national product in 2013 (the most recent data), compared to an average of 2.37 per cent in OECD countries. It emphasizes that the three federal granting agencies are severely underfunde­d, and strongly recommends a major federal reinvestme­nt in health research.

It is our wish that the recommenda­tions of this report be implemente­d immediatel­y, to bring about beneficial, effective and sustainabl­e change for research. The resulting synergy between federal and provincial government­s will enhance our research capacity, train tomorrow’s scientists, and provide tangible support for the developmen­t of a true knowledge society, for the greater benefit of all Canadians.

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