BIOTECHNOLOGY
Victor Barocas is a professor of biomedical engineering at the University of Minnesota with more than 100 published works in the field. Given his profession, the genesis of this puzzle (spelled out at 71-Across) is probably obvious. Besides the theme, Victor included colorful fill like 8- and 29-Across and 8-, 43-, 56-, 82- and 100-Down — all of which help make for enjoyable solving. This is Victor’s 14th crossword for The Times and his fifth Sunday in the past year. — W.S. ACROSS
1 Homeowner’s action,
for short
5 Things blockers block 8 1979 film inspired by
Janis Joplin’s life 15 Indistinct shape 19 Receptionist on “The
Office”
20 Be bothered by
22 Island nation west
of Fiji
23 Possible consequence
of default, in brief 24 Wildflower with spiky,
purplish blooms 25 Secure
26 Ruling family of Edward I
27 Finished
28 Adam’s ____ (water) 29 Hole in one’s head 31 Humpty Dumpty, e.g. 32 “Dallas” family name 33 The Anne of “Anne of
the Thousand Days” 35 Feverish
36 Put back on 38 Insinuating
39 —
40 James who won an Emmy two years in a row for the same role on different shows 42— 45 Ignorant person, in
slang 47 Security-system array 49 Total 51 Angered by
53 Ancient monuments 54 Gaston ____, “The Phantom of the Opera” novelist
55 Latte choice,
informally
58 The “she” in the lyric “She would merengue and do the cha-cha”
59 W.W. I French biplane 60 Capital of Albania
61 Like much of Iowa 63 1980 Olympic hockey champs
66 Up
68 Shark fighters 70 “Believe ____ not!” 71 Biological manipulation suggested four times by this puzzle
74 First Africanamerican Davis Cup player
75 Beethoven’s
birthplace 76 Comprehension 77 Tender spot?
78 Like the sun god Inti 79 Some liturgical
vestments
81 ____ de Triomphe
83 It’s down in the dumps
86 First National Leaguer to hit 500 home runs
87 Fall color providers 88 Some instant coffees 90 Cheyenne Mountain
org.
92 Stays out of
93 Closes in a thin membrane 95 Disappointing response to an application 98 Remarkable ability of
a starfish
99 Use a rototiller on, say
101 Lack of variation 103 “ER” actress Laura 105 Turn out
106 Service with more than
1.5 billion users 107 Home of the Latino Walk of Fame, informally
108 Composer of the “London” symphonies
111 Big e-cigarette brand 113 Anti-athlete’s foot brand
115 Good for leaving handprints in
116 State without reservations
117 —
119 Provider of child support?
120 —
121 Polynesian carving 122 Dreamer
123 Half in advance? 124 Unique individual 125 Starting point 126 Broadway’s “____ Todd”
127 “Hamilton” Tony nominee Phillipa ____
128 Loch ____, site of Urquhart Castle
DOWN
1 Goes through physical
therapy
2 Anon 3 Beethoven’s only opera 4 As a rule
5 City that ancient Greeks called Philadelphia 6 Christian with a big
house
7 Winter vehicle
8 Mike and Carol Brady,
e.g.
9 Berry receiving much attention in the 2000s
10 Bambi’s aunt
11 Bit of ancient script 12 Ingredient in some health-food supplements
13 Not occurring
naturally 14 Romanian-born writer once in the French Academy 15 Cook on the outside 16 Tribe of Moses and
Aaron
17 Available to the public 18 Wimbledon champ,
1976-80
21 First takes
29 Gag item floating in Halloween punch 30 Brother on “Frasier” 32 Breadwinner
34 Ancient Dead Sea
land
37 Woozy
39 —
40 Rooms with views 41 Forecast
42 —
43 Phrase of agreement 44 Subject for Kinsey 46 Olden Tokyo
48 Flower part 50 Roman emperor before Hadrian 52 “Nyah, nyah!” e.g. 55 Nursery sight 56 Insurance for the
crash-prone
57 Big story
60 Start of a countdown 62 Composer Schoenberg
64 Repair material 65 Skeptically
67 Apostle called “the
Zealot”
69 Launched 71 Didn’t know but said
something anyway 72 Midlength records, for
short
73 Full of spirit
78 From Shiraz or Tabriz 80 Country star Womack 82 Greenbacks 84 1990s-2000s compact
car
85 Smelter’s supply 87 Locale for un
capitaine
88 It doesn’t need land
to land 89 Sometimes-white animal
91 Rackets
94 Smiles smugly
96 Twist together
97 X’s
100 Chafe
102 QB protection squads
104 Companions of Dionysus
105 John Wilkes Booth’s actor brother 106 Wikipedia’s logo 107 Refrain from nursery singing
108 “In time we ____ that which we often fear”: Shak.
109 Devoted
110 Make into a couple 112 Magazine with the motto “Cure ignorance”
114 Staff note
117 —
118 First name in spy literature
120 —