The Standard (St. Catharines)

Our government leaders must up their game to complete victory against COVID-19

- JAMES DOUKETIS Dr. James Douketis is a professor of medicine and the David Braley-nancy Gordon Chair in Thromboemb­olic Disease at Michael G. Degroote School of Medicine, Mcmaster University.

The incredible opportunit­y that science has bought for all of humanity with the vaccines developed to stop the spread of COVID-19 means it is time — time to save lives, reduce hospitaliz­ations, and open up our schools and economy. That advantage will be lost, however, if it is not implemente­d with the same urgency, collaborat­ion and amazing skill that went into creating the vaccines and making them so speedily available to society. It is deeply dispiritin­g to see Canada’s vaccine rollout stall amid global comparison­s while people who need the vaccine continue to get sick.

As one who is familiar with the scientific process, I know that the effort that has gone into finding ways to test for, prevent, and treat COVID-19 is nothing short of astonishin­g, even when compared to the massive push to do the same for HIV-AIDS, Ebola and H1N1. We also are awestruck at the speed with which the SARS-COV-2 vaccines have been developed, and elated at how effective and safe they are.

From my experience in treating patients with COVID-19 I have seen firsthand how potentiall­y devastatin­g a disease it can be: within a mere few hours, patients can go from needing low level care to requiring life-support with mechanical ventilatio­n. Despite our best efforts, I have seen the limitation­s of existing and new therapies to treat COVID-19. Our best treatment, corticoste­roids — an old standby in clinical medicine when “nothing else works” — reduces mortality by about one-third. Other treatments, including antiviral agents, anti-inflammato­ry drugs and convalesce­nt plasma, have marginal or no benefit, and some are even harmful.

The absence of highly effective treatments for COVID-19 coupled with the desire for our society to reopen our schools, revitalize our economy, and resume healthy social activities places vital urgency on the one thing that will prevent disease and restore normalcy in our society: vaccines.

It’s easy to forget that at the start of the pandemic experts were warning an 18-month timeline for delivering safe and effective vaccines might be too optimistic. At this time last year, there was uncertaint­y as to whether a vaccine would work at all: we were dealing with a new virus and there were no effective vaccines for other coronaviru­ses that cause the common cold.

But the unparallel­ed, wartimelik­e mobilizati­on of scientific skill, resources, and dedication to a common goal culminated in producing not one, but multiple effective and safe vaccines, of which several are in current use or poised to become available. Scientists, research institutes, manufactur­ers, and government­s worked together with astonishin­g speed, while at the same time not sacrificin­g any of the scientific and ethical checks and balances imperative in developing these vaccines, especially in this time of widespread misinforma­tion and vaccinatio­n skepticism.

In the face of this massive worldwide effort and amazing scientific advances, it is incredibly frustratin­g to see this achievemen­t being held up by what should be less challengin­g problems: procuring doses and getting vaccines into the bodies of the people who need it in a timely manner. Even weeks of delay can mean more hospitaliz­ations and more deaths.

Social distancing and masks are important components to prevent virus transmissi­on but they are being implemente­d to buy us time, which they have done, until a vaccine is available. Ultimately, the vaccine is the surest way we have to prevent virus spread and disease.

Earlier this year, I was a signatory to a letter by 14 Mcmaster professors of medicine sent to federal and provincial government leaders, urging accelerate­d and sustained action on the procuremen­t, distributi­on and administra­tion of vaccines.

We have not lost sight of the complexity of delivering an uneven supply of a fragile and life-saving commodity fairly across our massive country and can sympathize with those in government who bear a heavy responsibi­lity to get this job done. However, the reality is we need to do better — far better — and expect the same level of commitment from government­s as that shown by our scientists, doctors, nurses and many others.

The scientific community, alongside thousands of front-line health-care workers, have carried the ball to the one-yard line. Now, our government leaders need to up their game and carry the ball across the goal-line.

It is deeply dispiritin­g to see Canada’s vaccine rollout stall amid global comparison­s while people who need the vaccine continue to get sick

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