Cancer drugs darken grey hair
CHICAGO — Cancer patients’ grey hair unexpectedly turned youthfully dark while taking novel drugs, leaving doctors scratching their heads.
Chemotherapy is notorious for making hair fall out, but the 14 patients involved were all being treated with new immunotherapy drugs that work differently and have different sideeffects.
A Spanish study suggests that may include restoring hair pigment, at least in patients with lung cancer.
With the first patient, “we thought it could be an isolated case,” said Dr. Noelia Rivera, a dermatologist at Autonomous University of Barcelona.
But, she said, the research team found the same thing when it asked other patients for photos from before treatment.
The 14 cases were among 52 lung cancer patients being followed to see whether they developed bad sideeffects from the drugs Keytruda, Opdivo and Tecentriq.
While most patients did not have a hair-colour change, the 14 cases suggest it’s not an isolated finding.
In 13 patients, hair turned darkish brown or black. In one patient, it turned black in patches. In another odd twist, the same drugs have been linked previously with hair losing colour in patients with another cancer, melanoma.
All but one of the 14 patients in the Spanish study had at least stable disease and responded better to treatment than other patients, suggesting that hair darkening might be an indication that the drugs are working, the researchers said.
Rivera said they are continuing the study to search for an explanation and to see if the cases are a fluke.
The study was published online this month by the Journal of the American Medical Association.
Rivera noted that the study drugs have serious side-effects that make them unsafe for healthy people. But if it’s confirmed that they do change hair colour, a different drug could be developed to treat grey hair, she said.