Closer to Alzheimer’s remedy
Early diagnosis is improving and likely key to starting therapy that may halt dementia
After decades of feverish work, researchers have so far failed to find a treatment for Alzheimer’s that halts or reverses the inexorable loss of memory, function and thinking ability that characterize this feared illness.
But researchers have been quite successful at devising ways to diagnose Alzheimer’s earlier and earlier. And that capability has emerged alongside evidence of a tantalizing possibility: that if you can catch the disease early enough — ideally when symptoms of confusion or memory loss are just emerging, or before — some therapies already in hand might essentially halt its progress.
For anyone who detects some mental slippage and wonders: “Is it Alzheimer’s?” the current state of dementia research raises a very real, and very wrenching, dilemma: If I can know, do I want to know?
That is, if it’s Alzheimer’s disease, would I do anything differently? Would there be some benefit in knowing for my loved ones, for myself?
Newly unveiled research results are bringing some clarity to such deliberations. And other new research, published Wednesday in the journal Neurology, proposes a new diagnostic tool that might be able to detect Alzheimer’s, and distinguish it from another form of dementia, more simply and cheaply than does the best test now available.
At the Alzheimer’s Association International Conference in London last week, researchers reported their preliminary findings from a trial that is testing the impact of diagnostic testing for Alzheimer’s disease on nearly 19,000 people.
All of these study participants — largely people in their 70s, all with a diagnosis of either “mild cognitive impairment” or atypical dementia — are living with the unconfirmed suspicion that they have Alzheimer’s. The study is underwritten by the U.S. Centers for Medicare & Medicaid Services and the Alzheimer’s Association. It set out to find out whether knowing — getting the test that would offer either confirmation or reprieve — would change the way that patients with cognitive troubles are treated, or the way that they plan their lives.
The preliminary results suggested it did. After getting the results of a PET brain scan to detect and measure amyloid deposits, which are the key hallmark of Alzheimer’s disease, roughly two-thirds of the subjects saw their medication regimens changed or were counselled differently by their doctors about what to expect.
That new information might have guided family caregivers in planning their own futures, or prodded patients to make financial decisions and power-ofattorney assignments sooner. Some who learned that they did not have Alzheimer’s discontinued medications that can have unpleasant side-effects. Others learned they do have Alzheimer’s and decided to enrol in clinical trials that will test new drugs.
A second study presented in London analyzed data from several studies, and found that in a large population of research participants with cognitive concerns, brain amyloid PET scans led to a change in diagnosis in about 20 per cent of cases.
“People should know what’s coming,” said Dr. Maria Carrillo, chief science officer for the Alzheimer’s Association.
The PET scan bore bad news for Ken Lehmann, who enrolled last year in the IDEAS trial, short for Imaging Dementia — Evidence for Amyloid Scanning. After his long, slow decline that has flummoxed doctors, Lehmann’s brain scan clearly showed he has Alzheimer’s disease.
The certainty that has brought has been a long time coming. When Lehmann began withdrawing from friends, forgetting to pay bills and having trouble following conversations, he was just 58. Now, he’s 80.
Ken had always been considered a “Renaissance man” — a furniture-company executive who rebuilt Porsches, played basketball and loved to entertain friends, said his wife, Mary Margaret Lehmann. But as years passed, his judgment seemed off. He would lose track of points he was making, and sometimes of where he was at.
It would take the loss of their home and a business bankruptcy for the Lehmanns to demand answers to what was going on. In 2009, they moved from Sacramento, California, to Edina, Minnesota, to live with a daughter. And there, at last, they found a neurologist who, despite initial skepticism (“but he presents so well!” the doctor proclaimed), diagnosed dementia.
For the Lehmanns and many patients and families similar to them — as well as for neurologists — that diagnosis is often just the beginning of a deeper mystery.
Alzheimer’s disease is the most feared and most common form of dementia, accounting for between 60 per cent and 80 per cent of all dementia cases diagnosed. But at least seven other forms of dementia, and dementia linked to the movement disorder Parkinson’s disease, can cause loss of memory, reasoning, judgment and the ability to speak, comprehend and care for oneself.
Being able to distinguish which form of dementia a patient has should help doctors and caregivers to make better choices.
But it’s a question that until recently could be answered only after death. At that point, a post-mortem examination of the brain could be done to look for the built-up clumps and tangles of beta-amyloid proteins, the overall shrinkage and the loss of neurons in the brain’s hippocampus that are, collectively, the hallmarks of Alzheimer’s.
No more. Improved medicalimaging technologies developed over the last decade have made it possible to peer inside the brain of a living patient, detect and measure the accumulation of betaamyloid, and make a definitive diagnosis.
In 2012, the U.S. Food and Drug Administration took a first step in making such imaging possible, giving its blessing to the imaging agent florbetapir F18, which binds to amyloid aggregates in the brain and allows a PET scan to be used to make the diagnosis. In 2013, two new imaging agents won FDA approval, and new imaging agents and techniques promise ever more precise means to visualize and diagnose Alzheimer’s in the brain.
On Wednesday, research published in the journal Neurology suggested that transcranial magnetic stimulation, a technique that can selectively turn up or down activity in different parts of the brain, could prove useful in distinguishing between Alzheimer’s disease from frontotemporal dementia.
In many ways, Ken Lehmann’s symptoms fit neatly into a diagnosis of frontotemporal dementia. A form of cognitive impairment that typically becomes evident earlier than most cases of Alzheimer’s, FTD often affects judgment, personality and verbal communication. This form of dementia progresses as inexorably as does Alzheimer’s. But its typical course differs slightly.
As an enrollee in the IDEAS trial, Lehmann was prepared to learn what it was he had.
“I had come to the conclusion they just don’t know,” said Lehmann, now 80, from his home in Minnesota. “In seven years, my journey of decline has been very miniscule, and they don’t know why.”
It turns out, he added, “I have all the biomarkers of Alzheimer’s disease.”
Once he and his wife learned that, they stepped up their preparations for further decline. And they redoubled their efforts to do things that bring joy, and that may slow Ken’s decline as well.
They follow a diet rich in fatty fish, healthful fats and fruits and vegetables, and Ken does woodworking. He also sings in a Minneapolis chorus, Giving Voice, with other dementia patients. He has regained a long-lost ability to read music.
“Just not knowing is very disconcerting,” says Mary Margaret, who is her husband’s principal caregiver. “I don’t know what the timeline is, but I now know what the needs are, in terms of financial and legal needs and end-oflife issues. Those all need to be planned for ahead of time, and now we have all of that in place. To me, that’s a safety net.”