1010例早期先兆流产患者中医证型分布及妊娠结局相关因素分析

1.首都医科大学附属北京中医医院，北京 100010；2.北京市中医研究所，北京 100010

黄玉华1，柯海 1，魏颖楠 1，郭婧 1，徐鸿燕 1，胡晶 2

摘要：目的 探讨早期先兆流产患者中医证型的分布规律，分析其妊娠结局的相关因素。方法 纳入 1010

例早期先兆流产住院患者，采用 Excel2010建立数据库，采集患者年龄、既往月经情况、流产次数、不良妊娠

次数、发病节气、发病时孕周、中医证型及妊娠结局（出院时间≥3 个月），分析中医证型的分布规律，以及

影响妊娠结局的相关因素。结果 1010 例患者中，肾虚证 762 例（75.4%），血热证 178 例（17.6%），气血虚

弱证 40 例（4.0%），血瘀证 15 例（1.5%），肝郁证 15 例（1.5%）。不同证型在各年龄段、孕周间的分布差异

有统计学意义（P＜0.01），不同证型的既往月经情况、流产次数、不良妊娠次数、发病节气差异无统计学意义（P＞0.05）。成功随访 698 例，其中妊娠成功 567 例（81.2%），妊娠失败 131 例（18.8%）。不同妊娠结局

的年龄比较差异有统计学意义（P＝0.026）。妊娠结局与年龄存在相关性（P＝0.012，OR＝1.063），与证型、流产次数、不良妊娠次数、既往月经情况、发病时孕周无明显相关性。结论 肾虚证为早期先兆流产最主要证型，证型分布与患者年龄段及发病时孕周有关，年龄是影响妊娠结局的相关因素。关键词：早期先兆流产；中医证型；妊娠结局DOI：10.3969/j.issn.1005-5304.2017.08.006中图分类号：R271.942.1 文献标识码：A 文章编号：1005-5304(2017)08-0022-05

Analysis on the Distribution of TCM Syndromes and Related Factors of Pregnancy Outcome of 1010 Cases of Early Threatened Abortion HUANG Yu-hua1, KE Hai1, WEI Ying-nan1, GUO Jing1, XU Hong-yan1, HU Jing2 (1. Beijing Hospital of TCM Affiliated to Capital Medical University, Beijing 100010, China; 2. Beijing Research Institute of TCM, Beijing 100010, China)

Abstract: Objective To discuss the distribution laws of TCM syndromes of early threatened abortion; To analyze the related factors of pregnancy outcome of early threatened abortion. Methods The study included 1010 hospital patients who were diagnosed as early threatened abortion. Excel2010 was used to establish database in order to collect general information such as the age, menstrual history, times of abortion and adverse pregnancy, incidence of solar term and pregnancy week, the type of TCM syndromes and the pregnancy outcome (at least 3 months after being out of hospital) of patients. The distribution laws of TCM syndromes, and related factors of pregnancy outcome were analyzed. Results Among the 1010 cases, 762 cases were with kidney deficiency syndrome (75.4%); followed by blood heat syndrome, a total of 178 cases, accounting for 17.6%; qi and blood deficiency syndrome, a total of 40 cases, accounting for 4%; blood stasis syndrome, a total of 15 cases, accounting for 1.5%; liver stagnation syndrome, a total of 15 cases, accounting for 1.5%. The distribution of TCM syndromes was statistical significance in the different age groups and the incidence of pregnancy week (P<0.01). But there was no statistical significance in menstrual history, times of abortion, times of adverse pregnancy, and the incidence of solar term (P>0.05). Among the 1010 cases, follow-up to 698 cases, 567 cases were successful pregnancies, accounting for 81.2% of the follow-up of patients; 131 cases were failed pregnancies, accounting for 18.8% of the follow-up of patients. In the study, it found