《古今名医临证金鉴•中风卷》用药规律研究

彭智远，曹雯，刘旺华，李花，钟银玲，周翠玲，张婕

湖南中医药大学，湖南 长沙 410208

摘要：目的 分析《古今名医临证金鉴•中风卷》用药规律，为临床提供参考。方法 查阅《古今名医临证金鉴•中风卷》收录的历代名医治疗中风疗效确切的处方，采用 Excel2003 建立数据库，统计用药频次。采用 SPSS17.0统计软件对常用药物进行聚类分析，以树状图展示结果。结果 共纳入 36位名医治疗中风的处方

112 首，涉及药物 204 味，用药频次 1169 次，其中高频药物（＞10次）有白芍、牛膝、当归、法半夏、茯苓

等。高频药物类别有补虚药（22.58%）、平肝息风药（12.31%）、活血化瘀药（11.89%）、清热药（11.46%）及

化痰止咳平喘药（8.72%）等。聚类分析表明高频药物（＞10 次）可聚为 6 类。结论 《古今名医临证金鉴•中风卷》以补虚药为主，配以平肝息风药、活血化瘀药、清热药及化痰止咳平喘药等治疗中风，可指导临床。关键词：古今名医临证金鉴；中风；用药规律；聚类分析

DOI：10.3969/j.issn.1005-5304.2017.10. 019

中图分类号：R2-05；R255.2 文献标识码：A 文章编号：1005-5304(2017)10-0081-04

Study on Medication Rules of Treatment of Stroke in Gu Jin Ming Yi Lin Zheng Jin Jian Zhong Feng Juan

PENG Zhi-yuan, CAO Wen, LIU Wang-hua, LI Hua, ZHONG Yin-ling, ZHOU Cui-ling, ZHANG Jie (Hunan University of Chinese Medicine, Changsha 410208, China)

Abstract: Objective To analyze the medication rules of the treatment of stroke in Gu Jin Ming Yi Lin Zheng Jin Jian Zhong Feng Juan; To provide references for the clinical treatment. Methods Prescriptions with confirmed efficacy of famous TCM doctors in the history in Gu Jin Ming Yi Lin Zheng Jin Jian Zhong Feng Juan was searched.

Excel2003 was used to establish database to analyze medication frequency. SPSS17.0 statistical software was used to conduct cluster analysis, and tree view was used to show results. Results Totally 112 prescriptions for the treatment of stroke of 36 famous TCM doctors were included in the study, including 204 kinds of Chinese materia medica and

1169 times of medication frequency. The high-frequency medicines (>10 times) were Paeoniae Radix Alba, Achyranthis Bidentatae Radix, Angelicae Sinensis Radix, Pinelliae Rhizoma Praeparatum, and Poria. The high-frequency medicine categories were tonifying deficiency medicine (22.58%), pacifying liver and wind medicine

(12.31%), activating blood and dispelling stasis medicine (11.89%), clearing heat medicine (11.46%) and dissipating phlegm, cough and asthma medicine (8.72%). Cluster analysis showed that high-frequency medicine (>10 times) could be clustered as 6 categories. Conclusion Gu Jin Ming Yi Lin Zheng Jin Jian Zhong Feng Juan focuses on tonifying deficiency medicine, accompanied with pacifying liver and wind medicine, activating blood and dispelling stasis medicine, clearing heat medicine and dissipating phlegm, cough and asthma medicine, which can be used to guide clinic.

Key words: Gu Jin Ming Yi Lin Zheng Jin Jian; stroke; medication rules; cluster analysis

基金项目：

国家自然科学基金（ 81202632、81373702、

81473567）；教育部博士点基金（20124323120003）；湖南省

自然科学基金（13JJ3097）；湖南省教育厅科研项目（14B134）；

湖南省高校创新平台开放基金（15K092）

通讯作者：刘旺华，E-mail：595413533@qq.com

中风又名脑卒中，是以猝然昏倒，不省人事，伴口眼歪斜、语言不利、半身不遂为主要症候的一类疾病。现代医学认为该病属脑血管疾病范畴，因其具有发病率高、复发率高、致残率高、病死率高的特点，故与心血管疾病、肿瘤、老年变性病并列为人类四大死亡原因疾病。历代中医名家对中风都有独到见解，