魏品康从痰论治胃癌用药规律研究

施俊 1，2，叶敏 2，陆烨 2，吕英1，指导：魏品康 2

1.上海中医药大学附属岳阳中西医结合医院，上海 200437；2.上海长征医院，上海 200003摘要：目的 分析魏品康教授治疗胃癌处方用药规律，为临床用药提供参考。方法 收集魏品康名老中医工作室门诊病案库（包括电子数据库和纸质病案库）收录的 2008 年 1 月－2015 年 12 月魏品康教授于上海长征医院中医科门诊治疗的胃癌病案。运用中医传承辅助平台V2.5软件建立数据库，采用频次分析、关联规则分析、复杂系统熵聚类等数据挖掘方法，分析处方中各种药物的使用频次、药物之间的关联规律和核心药物组合。结果 共收集 305首处方，包含 185味中药，其中使用频次较高的药物有法半夏、制天南星、鸡内金等；温性和寒性药物多见，多为苦、辛、甘味，多入胃经、脾经和肝经；频次较高的药物组合有法半夏-制天南星、法半夏-鸡内金、鸡内金-制天南星等；常见药对有枳壳-枳实、全蝎-蜈蚣等。获得不同药物组合模式的关联规则 36 条置信度＞0.99、核心组合 70 条、新处方 11 首。结论 魏品康教授治疗胃癌讲究从痰论治，治法以消痰散结为核心，常用药物以消痰散结为主，配合理气和胃、清热解毒。关键词：胃癌；数据挖掘；魏品康；用药规律

DOI：10.3969/j.issn.1005-5304.2017.10.020

中图分类号：R2-05；R273.52 文献标识码：A 文章编号：1005-5304(2017)10-0085-05

Study on Medication Rules of Professor WEI Pin-kang in Treating Gastric Cancer from Phlegm

SHI Jun1,2, YE Min2, LU Ye2, LV Ying1, Instructor: WEI Pin-kang2 (1. Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai

200437, China; 2. Shanghai Changzheng Hospital, Shanghai 200003, China)

Abstract: Objective To explore the medication rules of Professor WEI Pin-kang in treating gastric cancer; To provide references for clinical medication. Methods Gastric cancer cases treated by Professor WEI Pin-kang in TCM outpatient department of Shanghai Changzheng Hospital from January 2008 to December 2015 in WEI Pin-kang TCM Studio Outpatient Medical Cases (including electronic database and paper medical cases database). TCM Inheritance Support System V2.5 was used to build database. Frequency analysis, association rule analysis, complex system entropy clustering and other data mining methods were used to analyze frequency, medicine association rules and core medicine combination. Results Totally 305 clinical prescriptions including 185 kinds of Chinese materia medica were collected. The Chinese meteria medica with the high frequency were Pinellinae Rhizoma Praeparatum, Arisaematis Rhizoma Preparatum and Galli Gigerii Endothelium Corneum, etc. High frequency Chinese materia medica were with the properties of warm and cold, and with the flavors of bitter, spicy and sweet, to Stomach Meridian of Foot-Yangming, Spleen Meridian of Foot-Taiyin, and Liver Meridian of Foot-Jueyin. The medicine combinations with high frequency were “Pinellinae Rhizoma Praeparatum and Arisaematis Rhizoma Preparatum”, “Pinellinae Rhizoma Praeparatum and Galli Gigerii Endothelium Corneum”, and “Galli Gigerii Endothelium Corneum and Arisaematis Rhizoma Preparatum”. The common medicine pairs were “Aurantii Fructus and Aurantii Fructus Immaturum” and “Scorpio and Scolopendra”. Analysis showed 36 association rules of the confidence > 0.99.

70 core medicine combinations and 11 new prescription were obtained. Conclusion Professor WEI Pin-kang treats gastric cancer based on phlegm theory. The dissolving phlegm and eliminating stagnation medicine, regulating qi-folwing for harmonizing stomach medicine and heat-clearing and detoxifying medicine are commonly used.

Key words: gastric cancer; data mining; WEI Pin-kang; medication rules

基金项目：国家自然科学基金（81573762）；上海市进一步加快中医药事业发展三年行动计划（ZY3-RCPY-3-1016）；上海浦东

新区卫生系统重点学科建设项目（PWZxq2014-12）

通讯作者：魏品康，E-mail：czzyk73408@163.com