针灸治疗阿尔茨海默病取穴规律研究

刘源香，孙春全，杨继国

山东中医药大学，山东 济南 250355

摘要：目的 基于中医医案知识服务与共享系统（V1.2.8）挖掘针灸治疗阿尔茨海默病的取穴规律，为临床提供参考。方法 计算机检索中国知识资源总库（CNKI）、中文科技期刊数据库（重庆维普）、中国学术期刊数据库（万方数据）、中国生物医学文献数据库（CBM）收录的1996 年 1 月 1 日－2016 年 1 月 1日针灸治疗阿尔茨海默病临床研究文献。采用 Excel2007 建立数据库并录入中医医案知识服务与共享系统（V1.2.8），采用系统集成的频次分析、关联规则分析、穴对分析、核心处方分析等数据挖掘方法对纳入数据进行分析。结果 经筛选，共纳入针灸处方125首，涉及腧穴108个，总取穴频次998次，其中取穴频次最高的腧穴为百会（78次，

62.40%）。高频穴对有足三里-百会、足三里-三阴交、百会-四神聪等。主要核心处方为百会、足三里、四神聪、神门、太溪、三阴交、内关、太冲、丰隆、大椎、风池、肾俞、神庭、悬钟，次要核心处方为合谷、印堂、膻中、血海、膈俞、肝俞、脾俞、气海、阳陵泉、阴陵泉、上星。结论 中医医案知识服务与共享系统（V1.2.8）分析得出的针灸治疗阿尔茨海默病呆取穴规律可指导临床应用，但须注意随证加减。关键词：阿尔茨海默病；针灸；取穴规律；数据挖掘；中医医案知识服务与共享系统

DOI：10.3969/j.issn.1005-5304.2017.10.021

中图分类号：R2-05；R277.7 文献标识码：A 文章编号：1005-5304(2017)10-0090-04

Study on Rules of Acupoints Selection of Acupuncture and Moxibustion in Treatment of Alzheimer Disease

LIU Yuan-xiang, SUN Chun-quan, YANG Ji-guo (Shandong University of TCM, Ji'nan

250355, China)

Abstract: Objective To explore the rule of acupoints selection of acupuncture and moxibustion in treating Alzheimer disease based on TCM Knowledge Service and Sharing System (V1.2.8); To provide references for the clinic. Methods Literature about acupuncture and moxibustion for the treatment of Alzheimer disease in CNKI, Choingqing Weipu, Wanfang database, and CBM from 1st January, 1996 to 1st January, 2016 was searched.

Excel2007 was used to establish database and enter into TCM Knowledge Service and Sharing System (V1.2.8). The data were analyzed by data mining method such as frequency analysis, association rule analysis, point-to-pair analysis and core prescription analysis. Results After screening, 125 acupuncture prescriptions were included, involving 108 acupoints and 998 total acupoints selection frequency. Baihui had the highest frequency (78 times, 62.40%). The core acupoint combinations were Zusanli-Baihui, Zusanli-Sanyinjiao, and Baihui-Sishencong. The main core prescription was Bauhui, Zusanli, Sishencong, Shenmen, Taixi, Sanyinjiao, Neiguan, Taichong, Fenglong, Dazhui, Fengchi, Shenshu, Shenting, Xuanzhong. The second core prescription was Hegu, Yintang, Tanzhong, Xuehai, Geshu, Ganshu, Pishu, Qihai, Yanglingyuan, and Shangxing. Conclusion The rules of acupoints selection analyzed by TCM Knowledge Service and Sharing System (V1.2.8) for Alzheimer disease can be used to guide clinical application, but with modification according to symptoms.

Key words: Alzheimer disease; acupuncture and moxibustion; rues of acupoints selection; data mining; TCM Knowledge Service and Sharing System 阿尔茨海默病（Alzheimer disease，AD）又称老

基金项目：山东省自然科学基金（ZR2015HM062）；山东省重

点研发计划（2015GSF119020）

通讯作者：杨继国，E-mail：jiguoyang@126.com 年性痴呆，是一种以渐进性记忆力减退、失语、失用、失认、视空间能力损害、抽象思维和计算力损害、人格和行为改变为主要临床表现的退行性大脑变性疾

病[1]。AD 的发病率与年龄的增长呈正相关，多发于

65岁以上的老年人，严重影响患者的生活质量和身心