基于数据挖掘的唐旭东治疗功能性消化不良用药规律研究

李夏1，李敬华2，王凤云3，车慧3，张佳琪3，指导：唐旭东4

1.北京中医药大学研究生院，北京 100029；2.中国中医科学院中医药信息研究所，北京 100700；

3.中国中医科学院西苑医院，北京 100091；4.中国中医科学院，北京 100700

摘要：目的 采用数据挖掘方法分析唐旭东教授治疗功能性消化不良的用药规律，为临床治疗提供参考。方法 采集唐旭东教授 2016 年 1 月 1 日－2018 年 5 月 31日在中国中医科学院西苑医院门诊病历数据，建立标准化医案数据库。采用古今医案云平台V1.5系统集成的统计分析、聚类分析、复杂网络分析等方法，分析处方的证型频次、用药频次、药物属性（药性、药味、归经）、核心处方。结果 纳入病历 219 份，处方 219

首。高频证型有肝郁脾虚证（97次）、寒热错杂证（91 次）、气滞湿阻证（77次），高频药物有砂仁（198 次）、

炙甘草（167 次）、陈皮（151次），药性多温、微寒、平，药味多辛、苦、甘，多归脾、胃、肺、肝经。组方以香砂六君子汤和逍遥散为基础加减。结论 唐旭东教授治疗功能性消化不良多以健脾、疏肝、行气、化湿为法，注重恢复气机通降，平调寒热，多脏腑同治。关键词：唐旭东；功能性消化不良；数据挖掘；用药规律

中图分类号：R2-05；R259.7 文献标识码：A 文章编号：1005-5304(2020)03-0094-05

DOI：10.3969/j.issn.1005-5304.201906202 开放科学（资源服务）标识码（OSID）：

Study on Medication Laws of Tang Xudong for Treatment of Functional Dyspepsia Based on Data Mining

LI Xia1, LI Jinghua2, WANG Fengyun3, CHE Hui3, ZHANG Jiaqi3, Instructor: TANG Xudong4

1. Graduate School, Beijing University of Chinese Medicine, Beijing 100029, China; 2. Institute of Information on Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China;

3. Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China;

4. China Academy of Chinese Medical Sciences, Beijing 100700, China

Abstract: Objective To analyze the medication laws of Professor Tang Xudong for the treatment of functional dyspepsia through data mining methods; To provide references for clinical treatment. Methods Prof. Tang’s medical records from January 1st 2016 to May 31st 2018 in outpatient of Xiyuan Hospital, China Academy of Chinese Medical Sciences were set as data resources. A standardized medical record database was established, and system integration statistical analysis, cluster analysis, complex network and other methods of cloud platform of Ancient and Modern Medical Records V1.5 were used to analyze the frequency of syndrome types, medication frequency, features (properties, flavors, and belonging meridians), core prescriptions, etc. Results Totally 219 medical cases and 219 prescriptions were included. The high-frequency syndrome types were liver depression and spleen deficiency syndrome (97 times), cold-heat complicated syndrome (91 times), qi stagnancy and damp retention syndrome (77 times). The high-frequency Chinese materia medica were Amomi Fructus (198 times), Glycyrrhizae Radix et Rhizoma Praeparata cum Melle (167 times), Citri Reticulatae Pericarpium (151 times), most of which property belonged to warm, cold and mild, most of which flavor belonged to pungent, bitter and sweet, most of which belonged to spleen, stomach, liver and lung meridians. Prescriptions were modified based on Xiangsha Liujunzi Decoction and Xiaoyao Powder. Conclusion Prof. Tang’s treatment for functional dyspepsia mostly adopts the methods of strengthening spleen, smoothing liver, promoting qi and eliminating dampness, emphasize the regulation of qi, the balance of cold and heat and simultaneous treatment for multiple zang-fu organs.

Keywords: Tang Xudong; functional dyspepsia; data mining; medication laws基金项目：国家自然科学基金面上项目（81673853）；国家自然科学基金青年基金（81804078）通讯作者：唐旭东，E-mail：txdly@sina.com