Fighting Coronavirus: Imported infection spreads across province
Virologists fear new virus variety more infectious, harder to detect
An extra-long infection chain in Harbin, Northeast China’s Heilongjiang Province, has extended to more neighboring regions, sounding the alarm over the infectivity of the imported case.
North China’s Inner Mongolia Autonomous Region became the second provincial region to be affected by patients in Heilongjiang, following Liaoning Province.
Hulun Buir government said the confirmed patient in the Inner Mongolia city is related to Harbin, a city where an imported case from the US has caused infections of at least 50 people.
Epidemiologists and virologists reached by the Global Times on Monday said the long infection chain from Harbin has transformed their knowledge of the coronavirus, which may be a different genotype from the one that spread in China earlier, and they stressed the acute importance to contain the virus soon.
Zeng Guang, chief epidemiologist of the Chinese Center for Disease Control and Prevention, said “We shall pay great attention to the small-scale outbreak in Harbin, which has a clear and long infection chain, and they have exposed some new characteristics of the coronavirus,” indicating the unsuspected infectivity of the disease.
Yang Zhanqiu, deputy director of the pathogen biology department at Wuhan University, told the Global Times on Monday that the genotype of the coronavirus that spread through the Harbin chain might have come from overseas and Chinese people might be more susceptible to this new coronavirus genotype.
Yang warned the outbreak in Harbin must be given full attention. If it is not fully controlled, the regional outbreak would spread widely because it comes as China is resuming work and production and population flows are recovering.
The case also underlined the importance of preventing imported cases from spreading,
Yang said, noting that closedloop management and prevention of community spread are critical.
The original imported case in Harbin was a Chinese passenger surnamed Han who flew from the US on March 19. Contact tracing revealed that more than 50 cases of COVID-19 were related to her, either directly or indirectly, including secondary clustered infections at two hospitals. Some 4,000 people are under screening to check for close contacts due to the hospital outbreak.
Han took four nucleic acid tests and antibody tests, all negative, but passed the virus to her neighbor. Local health authorities later confirmed Han had been infected with the COVID-19. Beijing on April 14 also reported an imported case from the US who was confirmed to be infected after negative test results at a hospital and the quarantine center.
“Han’s case has warned us that there may be inadequacy in our detection methods. Is our test sensitive enough? Why does the coronavirus have such strong infectivity while frequent tests are negative?” Zeng asked.
Yang, as a virologist, noted that a new genotype of the coronavirus could affect the effectiveness of China’s test kits, which are developed based on virus types previously discovered in China.