Cutting-edge cell therapy improving survival rate

CUTTING-EDGE cell therapies are rapidly gaining ground, raising hope for patients with incurable diseases, according to the first Zhangjiang International Summit on Cell Therapy.

The two-day meeting opened at the newly established Zhangjiang Cell Industrial Park in the Pudong New Area yesterday.

Researchers, scholars and executives from leading pharmaceutical firms from 16 countries and regions including China, the UK and the US shared their pioneering research on cell therapies and outlined possible approaches in the treatment of diabetes, cancers, eye diseases and heart failure.

Tian Zhigang, an academician with the Chinese Academy of Sciences, expressed optimism about NK cell therapy in the treatment of cancer.

NK cells, natural killer cells, are a type of white blood cell and a component of the immune system. Tests have shown they are first to act against disease, before the T cells that are perhaps today’s most commonly known white blood cells for their use in CAR-T therapy against cancer.

What we know about NK cell today is just the tip of iceberg, Tian said.

Fighting heart failure

In early 2016, the US government initiated the Cancer Moonshot, aiming to replace radiotherapy and chemotherapy with cell therapy after surgery. “It sounded very futuristic in 2016. But it has rapidly progressed,” Tian said.

Yuji Shiba, a professor from Shinshu University in Japan, injected induced pluripotent stem cells, which have the potential to develop into any cell in the body, into monkeys with heart failure. The cells turned to cardiac cells and the monkeys survived.

“We hope this can be used to treat heart failure,” he said. “Today, most patients will die within 10 years after they are diagnosed, and the last thing and also the only useful way to live is to have heart transplant. But the number of such surgeries has been declining over 20 years. So we need some new treatments.”

The Shanghai Science and Technology Commission approved the establishment of the Zhangjiang Cell Industrial Park in June. Currently, it has more than 70 companies, from cell therapy developers such as Novartis, equipment manufacturers such as GE, third-party medical testers such as BGI and hospitals such as the East Branch of Fudan University Shanghai Cancer Center.