Chinese scientists break key barrier by cloning monkeys
LONDON, (Reuters) - Chinese scientists have cloned monkeys using the same technique that produced Dolly the sheep two decades ago, breaking a technical barrier that could open the door to copying humans.
Zhong Zhong and Hua Hua, two identical long-tailed macaques, were born eight and six weeks ago, making them the first primates — the order of mammals that includes monkeys, apes and humans — to be cloned from a non-embryonic cell.
It was achieved through a process called somatic cell nuclear transfer (SCNT), which involves transferring the nucleus of a cell, which includes its DNA, into an egg which has had its nucleus removed.
Researchers at the Chinese Academy of Sciences Institute of Neuroscience in Shanghai said their work should be a boon to medical research by making it possible to study diseases in populations of genetically uniform monkeys.
But it also brings the feasibility of cloning to the doorstep of our own species.
“Humans are primates. So (for) the cloning of primate species, including humans, the technical barrier is now broken,” Muming Poo, who helped supervise the programme at the institute, told reporters in a conference call.
“The reason ... we broke this barrier is to produce animal models that are useful for medicine, for human health. There is no intention to apply this method to humans.”
Genetically identical animals are useful in research because confounding factors caused by genetic variability in non-cloned animals can complicate experiments. They could be used to test new drugs for a range of diseases before clinical use.
The two newborns are now being bottle fed and are growing normally. The researchers said they expect more macaque clones to be born over the coming months.
Since Dolly - cloning’s poster child - was born in Scotland in 1996, scientists have successfully used SCNT to clone more than 20 other species, including cows, pigs, dogs, rabbits, rats and mice.
Similar work in primates, however, had always failed, leading some experts to wonder if primates were resistant.
The new research, published on Wednesday in the journal Cell, shows that is not the case. The Chinese team succeeded, after many attempts, by using modulators to switch on or off certain genes that were inhibiting embryo development.