U.S. man recovering after ‘breakthrough’ pig-heart transplant

CHICAGO, (Reuters) - A U.S. man with terminal heart disease was implanted with a genetically modified pig heart in a first-of-itskind surgery, and three days later the patient is doing well, his doctors reported yesterday.

The surgery, performed by a team at the University of Maryland Medicine, is among the first to demonstrate the feasibility of a pigto-human heart transplant, a field made possible by new gene editing tools.

If proven successful, scientists hope pig organs could help alleviate shortages of donor organs.

“This was a breakthrough surgery and brings us one step closer to solving the organ shortage crisis. There are simply not enough donor human hearts available to meet the long list of potential recipients,” Dr. Bartley Griffith, who surgically transplanted the pig heart into the patient, said in a statement.

“We are proceeding cautiously, but we are also optimistic that this first-in-the-world surgery will provide an important new option for patients in the future,” Griffith added.

For 57-year-old David Bennett of Maryland, the heart transplant was his last option.

“It was either die or do this transplant. I want to live. I know it’s a shot in the dark, but it’s my last choice,” Bennett said a day before his surgery, according to a statement released by the university.

To move ahead with the experimental surgery, the university obtained an emergency authorization from the U.S. Food and Drug Administration on New Year’s Eve through its compassionate use program.

“The FDA used our data and data on the experimental pig to authorize the transplant in an end-stage heart disease patient who had no other treatment options,” said Dr. Muhammad Mohiuddin, who heads the University’s program on xenotransplantation - transplanting animal organs into humans.

About 110,000 Americans are currently waiting for an organ transplant, and more than 6,000 patients die each year before getting one, according to organdonor.gov.