En­sur­ing health­ier, hap­pier Lives…

Business Sphere - - COVER STORY - By Deepak Khattar, Chief of News Bureau and also of Manoshi Sinha

Akums is In­dia’s sin­gle largest Con­tract Re­search and Man­u­fac­tur­ing (CRAMS) or­ga­ni­za­tion re­spon­si­ble for man­u­fac­tur­ing ap­prox­i­mately 11-12 % of all drugs con­sumed in the coun­try. The or­ga­ni­za­tion is led by Mr. San­jeev Jain and Mr. San­deep Jain (Co-founder, Di­rec­tors) and of­fers a com­pre­hen­sive range of ser­vices start­ing from for­mu­la­tion devel­op­ment to mar­ket launch all en suite. Its eleven state of the art fa­cil­i­ties are equipped to pro­duce all mod­ern dosage forms — tablets, hard gela­tine cap­sules, soft gela­tine cap­sules, pow­der in sa­chets, liq­uid syrups and sus­pen­sions, in­jec­tions, eye/ear drops, oint­ments, creams, gels, lo­tions, ayurvedic and herbal preparations, nu­traceu­ti­cal and cos­metic preparations and many more. Of the com­pany’s eleven man­u­fac­tur­ing fa­cil­i­ties nine are lo­cated in Harid­war and the two up­com­ing fa­cil­i­ties are lo­cated in Guwa­hati.

Un­der the aegis it’s Co­Founder- Di­rec­tors— Mr. San­jeev Jain and Mr. San­deep Jain, the com­pany wants to bring in newer, bet­ter, high qual­ity treat­ments to the masses so that it is sim­pler for pa­tients around the world to man­age their health and lives in a man­ner that suits them.

Akums state of the art man­u­fac­tur­ing fa­cil­i­ties are fit­ted with the most ad­vanced equip­ments and ma­chiner­ies, bring­ing in world-class health­care so­lu­tions within easy reach, our fa­cil­i­ties in­clude:

• Plant 1: Oral Dosage Forms— Tablets, Hard gelatin cap­sules, Soft gel Cap­sules, Pow­ders

• Plant 2: Liq­uid Dosage Forms— Syrups, So­lu­tions, Sus­pen­sions, Oral Jel­lies

• Plant 3: Ster­ile Par­enter­als— Liq­uid In­jec­tions, Dry Pow­der In­jec­tions, Eye/Ear/Nasal Drops, Lyophilized In­jec­tions

• Plant 4: Hor­monal Preparations— Tablets, Hard/soft gelatin cap­sules, In­jecta­bles, Liq­uid Orals, Topi­cals

• Plant 5: Derma-Cos­met­ics— Oint­ments, Creams, Gels, Pastes, Lo­tions, Sham­poos, Face packs, Scrubs

• Plant 6: US-NSF Ap­proved Ded­i­cated Ayurvedic, Herbal and Nu­traceu­ti­cal fa­cil­ity—Tablets, Liq­uids, Hard gelatin cap­sules, Soft gel Cap­sules, Pow­der in Sa­chet

• Plant 7: Multi ca­pa­bil­ity fa­cil­ity— Oral Solids, Par­enter­als, Top­i­cal, FFS Pkg (Ster­ile and non-ster­ile)

• Plant 8: Ded­i­cated Peni­cillin fa­cil­ity—Tablets, Cap­sules, Dry Syrups

• Plant 9: Ded­i­cated Cephalosporins fa­cil­ity—Tablets, Cap­sules, Dry Syrups, Ready to drink syrups

• Plant 10: Multi ca­pa­bil­ity fa­cil­ity—Oral Solids, Par­enter­als, Top­i­cal

• Plant 11: Multi ca­pa­bil­ity fa­cil­ity—Oral Solids, Par­enter­als, Top­i­cal

Man­u­fac­tur­ing Ex­cel­lence

The com­pa­nies sus­tained ad­her­ence to qual­ity and com­pli­ance has helped de­velop a unique brand in an oth­er­wise crowded in­dus­try. It en­joys a unique mar­ket po­si­tion with al­most nil com­pe­ti­tion from other man­u­fac­tur­ers ply­ing in the same mar­ket. The sheer va­ri­ety and breadth of its op­er­a­tions re­mains un­ri­valled so far. The com­pany has strate­gi­cally

aligned its man­u­fac­tur­ing ca­pac­i­ties with cur­rent mar­ket trends and fu­ture fore­casts. With huge man­u­fac­tur­ing ca­pac­i­ties on of­fer, mar­ket­ing part­ners have had the op­por­tu­nity to uti­lize their cap­i­tal on sell­ing ac­tiv­i­ties, while main­tain­ing a lean in­fra­struc­ture and mit­i­gat­ing risks from re­dun­dant re­sources. With strict qual­ity pa­ram­e­ters al­ready in place, our part­ners trust us with their largest brand.

High­est Qual­ity Ev­ery Time

As the coun­try’s largest fin­ished drug man­u­fac­turer, the com­pany is re­spon­si­ble for the health and well­be­ing of mil­lions of in­di­vid­u­als. It takes this re­spon­si­bil­ity very se­ri­ously, en­sur­ing that ev­ery dosage unit that leaves their sites lives up to the most strin­gent qual­ity stan­dards. It is one of the few providers who of­fer cus­tom­ized, ded­i­cated man­u­fac­tur­ing units, tai­lored to the ex­act needs of our val­ued part­ners. The com­pa­nies’ stream­lined pro­cesses, ex­haus­tive pro­to­cols and doc­u­men­ta­tion make the en­tire man­u­fac­tur­ing process fool­proof and sus­tain­able. The com­pany be­lieves that qual­ity is built into the prod­uct and that test­ing of the fin­ished drug prod­uct alone is in­suf­fi­cient for con­trol of prod­uct qual­ity. GMP guide­lines cover all as­pects of pro­duc­tion - from the start­ing ma­te­ri­als, premises, and equip­ment to the qual­i­fi­ca­tions, train­ing and per­sonal hy­giene of staff and man­age­ment. Man­u­fac­tur­ing con­trols have been in­stalled at var­i­ous points to en­sure high prod­uct qual­ity at ev­ery stage of the value chain.

Con­tin­u­ous In­no­va­tion

The com­pany uti­lizes a sig­nif­i­cant per­cent­age of its rev­enue for R&D ac­tiv­i­ties. Its team of sci­en­tists is al­ways at work try­ing to de­velop for­mu­la­tions that help our clients de­liver what they have promised. Unique Tech­nol­ogy based So­lu­tions Apart from of­fer­ing all stan­dard dosage forms, It have also de­vel­oped some spe­cial­ized for­mu­la­tions that in­volve a va­ri­ety of con­trolled-re­lease mech­a­nisms. These tech­nolo­gies can be ap­plied to a num­ber of prod­ucts to en­hance the pa­tient drug ex­pe­ri­ence: Bi­lay­ered Tablet En­hanced: This is a unique tablet with ben­e­fits of both bi-layered and tablet-in-tablet. This is a sin­gle tablet which of­fers an im­me­di­ate re­lease, sus­tained re­lease and de­layed re­lease func­tion

Oral Jel­lies: A unique dosage form de­vel­oped at Akums, this helps in taste mask­ing of drugs and easy dis­per­sion in a pleas­antly fla­vored oral jelly with a great mouth feel and organolep­tic prop­er­ties. Apart from silde­nafil jelly, we have also de­vel­oped al­en­dronate and al­ben­da­zole jelly. Some of our re­cent awards in­clude: Look­ing at the Fu­ture This is an in­no­va­tive dosage form de­signed in house at Akums, the pow­ders and tablets dis­in­te­grate on ad­min­is­tra­tion in the mouth. This dosage form is use­ful when quick on­set of ac­tion is re­quired. This is also very use­ful in pop­u­la­tions who have swal­low­ing dif­fi­cul­ties Bi-Layered Tablet: This tablet is made up of two dis­tinct lay­ers (usu­ally of dif­fer­ent col­ors) lying on top of another. Bi-layer tablets are very use­ful when two in­com­pat­i­ble API’s are to be ad­min­is­tered to­gether. Tablet-in-Tablet: This tech­nol­ogy al­lows for si­mul­ta­ne­ous ad­min­is­tra­tion of two dif­fer­ent drugs to­gether in a sin­gle tablet wherein a smaller tablet is en­cased within a larger outer tablet. This tech­nol­ogy im­proves pa­tient com­pli­ance, re­duces pill bur­den. Mul­ti­ple Tablets in a cap­sule: This tech­nol­ogy al­lows for the fill­ing of a sin­gle cap­sule shell with mul­ti­ple tablets and pills. This al­lows for devel­op­ment of a sin­gle dosage form for mul­ti­ple drugs and in the devel­op­ment of sus­tained re­lease forms In­lay Tablet: A type of layered tablet in which in­stead the core tablet be­ing com­pletely sur­rounded by coat­ing, top sur­face is com­pletely ex­posed, re­duc­tion in coat­ing forms a thin­ner tablet and lesser wastage due to de­fec­tive tablets from cap­ping of top coat­ing Gas­tric Float­ing Tablet: These tablets have been spe­cially de­signed for tar­geted ac­tion on the stom­ach lin­ing, in­stead of pass­ing into the in­tes­tine with other stom­ach con­tents; they keep float­ing in the stom­ach fluid and re­lease their con­tents in the stom­ach over time for tar­geted ac­tion. Ef­fer­ves­cent Tablets & Pow­der: Ef­fer­ves­cent pow­ders and tablets, which are dis­solved in wa­ter be­fore ad­min­is­tra­tion, have been for­mu­lated as an al­ter­na­tive dosage form for for­mu­la­tors to im­prove taste and for a gen­tle ac­tion on a pa­tient's stom­ach. Form, Fill & seal Tech­nol­ogy: It are one of the few play­ers in In­dia who of­fers FFS tech­nol­ogy for asep­tic pro­cess­ing. This tech­nol­ogy min­i­mizes op­er­a­tor in­ter­ven­tion and con­tam­i­na­tion risk in the fill­ing

and pack­ag­ing of liq­uid par­enteral drugs. In this tech­nol­ogy, poly­meric ma­te­rial is formed and sealed in­line to a con­tainer of choice, while the con­tainer is be­ing filled. Ready to use An­tibi­otic Syrups: Pe­di­atric an­tibi­otic preparations are usu­ally avail­able as dry pow­ders for re­con­sti­tu­tion with clean cool wa­ter. They have de­vel­oped ready to use an­tibi­otic syrups which do not need any re­con­sti­tu­tion, im­prov­ing com­pli­ance and ef­fi­cacy. prod­uct which then un­der­goes var­i­ous test­ing and an­a­lyt­i­cal pro­ce­dures. If all goes well, the prod­uct is filed for ap­proval. These ready to mar­ket prod­ucts are then po­si­tioned to its part­ners. This model helps in re­duc­ing the mar­ket to launch time while elim­i­nat­ing R&D costs for the part­ners. The com­pany cur­rently of­fers more than 2500 fin­ished for­mu­la­tions; in­clud­ing fixed dose com­bi­na­tions, across all ther­a­peu­tic seg­ments and dosage forms. It prod­uct of­fer­ing in­cludes:

• More than 565+ New DCGI ap­proved prod­ucts, out of these 22 prod­ucts have been in­tro­duced

Unique model: Ready to launch Prod­ucts

Apart from of­fer­ing tra­di­tional

con­tract man­u­fac­tur­ing ser­vices, Akums has cre­ated a unique model wherein it of­fers mar­ket ready prod­ucts to the client, ex­pe­dit­ing the mar­ket launch by sev­eral notches. They work through a model wherein they track mar­ket trends in other ge­ogra­phies to un­der­stand the lat­est ad­vances in var­i­ous ther­a­pies that are yet to have reached In­dia. They fol­low mar­ket and in­dus­try trends to un­der­stand cur­rent gaps and de­velop prod­ucts that make the best fit. They use their ex­ist­ing drug devel­op­ment set-up to for­mu­late the in­tended

first time in In­dia

• In ad­di­tion, we have filed for ap­proval of another 500 for­mu­la­tions which are cur­rently un­der DCGI re­view

Go­ing the Ex­tra Mile

Akums has emerged as an in­te­grated so­lu­tion provider for com­pa­nies seek­ing spe­cific devel­op­ment and busi­ness goals. Along with its core ser­vice of­fer­ing, they have stepped up to of­fer ad­vanced so­lu­tions for for­mu­la­tion devel­op­ment and test­ing. It is con­tin­u­ously look­ing at bet­ter ways to man­age for­mu­la­tion re­lated chal­lenges such as ease of ad­min­is­tra­tion, dos­ing fre­quency, taste mask­ing etc. From Devel­op­ment to Launch The phar­ma­ceu­ti­cal prod­uct devel­op­ment path­way is an in­ten­sive and com­plex process which re­quires deep sci­en­tific ex­per­tise and sig­nif­i­cant in­vest­ment of time and re­sources. At Akums, the prod­uct devel­op­ment path­way has been chan­nel­ized into de­vel­op­ing newer, ef­fi­cient prod­ucts through a con­trolled process. All re­sources and in­fra­struc­ture re­quired dur­ing the prod­uct devel­op­ment path­way are avail­able in-house; from the prod­uct con­cept, to the devel­op­ment batches, up till the fi­nal prod­uct, the en­tire process is con­ducted at our premises. This in turn trans­lates to com­plete con­trol over the qual­ity and de­liv­ery of the fi­nal prod­uct. Another point worth re­it­er­at­ing here is that all our pro­cesses are for­ti­fied with qual­ity checks at fre­quent points with ex­haus­tive doc­u­men­ta­tion all in line with cGMP and GLP guide­lines.

Cen­tral­ized Sta­bil­ity Test­ing Fa­cil­ity

The com­pany op­er­ates an ICH (Q1AR2) com­pli­ant Cen­tral­ized Sta­bil­ity Test­ing fa­cil­ity fit­ted with five walk-in Sta­bil­ity Cham­bers; we have the abil­ity to per­form sta­bil­ity stud­ies for all dosage forms in ev­ery phase of devel­op­ment.

CSR In­ter­ven­tions and Ac­tiv­i­ties at Akums

Cor­po­rate So­cial Re­spon­si­bil­ity (CSR) has never been a mere set of manda­tory le­gal pro­vi­sions at

Akums. The com­pany be­lieves that it is a moral and so­cial obli­ga­tion to give back to the so­ci­ety that has nur­tured us. Their CSR ac­tiv­i­ties are

spread over broad cat­e­gories like:

• En­vi­ron­ment

• Pub­lic In­fra­struc­ture

• Health and well be­ing

Save Ganga! Clean Ganga! On the lines of cen­tral Govern­ment’s Ganga Ac­tion plan, Akums launched their Ganga Clean­ing Ab­hiyaan. Un­der this ini­tia­tive, the com­pany fa­cil­i­tates la­bor and re­sources for ac­tiv­i­ties that re­duce pol­lu­tion lev­els in the river. This in­cludes equip­ments that re­move solid waste from the sur­face of the river; la­bor for de-silt­ing of the river bed etc. In ad­di­tion to this, Akums sends a spe­cial mis­sion who as­sists in re­mov­ing trash from the Ghats, af­ter fes­ti­vals like Ardh Kumbh, An­nual Kan­war Mela etc.,

Prad­han Mantri Socha­lay / Toi­let Yo­jana

On the lines of cen­tral Govern­ment’s Prad­han Mantri Socha­lay / Toi­let Yo­jana, the com­pany fa­cil­i­tated build­ing of toi­lets across fort nine govern­ment schools in Ut­trak­hand.

Green Belt Ini­tia­tive

Un­der this ini­tia­tive, trees were planted along an 18 km long stretch in the SIDCUL re­gion. Apart from this trees were also planted within metal canopies within the town area, around ghats, main bazaar ar­eas etc. These trees are now main­tained by

Akums who wa­ters and prunes them reg­u­larly.

Akums also cre­ated a green zone replica on the Dawaa Chowk in the SIDCUL re­gion, the beau­ti­ful chowk now is a con­stant re­minder of the im­por­tance of na­ture in our lives.

Pub­lic In­fra­struc­ture and Aware­ness Pro­grams

As one of the first ma­jor or­ga­ni­za­tion to come up in the SIDCUL re­gion,

Akums has con­trib­uted im­mensely to the pub­lic in­fra­struc­ture of the place. The com­pany has been re­spon­si­ble for the com­mis­sion of mod­ern roads at all its nine sites. Apart from roads which have linked these small towns and vil­lages to ma­jor high­ways, Akums has been in­stru­men­tal in set­ting up of pub­lic util­ity ser­vices like rain shel­ters for traf­fic po­lice, drink­ing wa­ter por­tals etc.

• Health Aware­ness and Free medicine Camps

• Blood Do­na­tion Camps

• Hep­ati­tis-B Aware­ness Pro­gram

• HIV/AIDS-Aware­ness Pro­gram

• First -Aid Train­ing Pro­gram

• Eye Ex­am­i­na­tion Camp

• Free Medicine Camps

Dis­as­ter Re­lief Ini­tia­tives at

Akums

Dev­as­tat­ing floods and land­slides rocked Kedar­nath in the year 2013; this was one of the worst nat­u­ral dis­as­ters to hit the coun­try in re­cent years. In its wake the floods left a huge toll death and de­struc­tion in the val­ley. Due to dif­fi­cult ter­rain and de­stroyed roads and bridges it be­came very dif­fi­cult to trans­port aid to the peo­ple who were stranded in the midst of all this de­struc­tion. Akums was one of the first com­pa­nies to reach with aid dur­ing this time. Re­lief aid con­sist­ing of clothes, medicines, food and other es­sen­tials was sent reg­u­larly for three weeks in truck con­sign­ments. The com­pany also sent a re­lief pack­age fol­low­ing earth­quake at Nepal.

Awards and Ac­co­lades

Akums has been hon­ored with well over 50 awards in the last five years in the ar­eas of qual­ity, re­li­a­bil­ity, in­no­va­tion and pro­duc­tiv­ity. We are es­pe­cially proud of our re­cent in­clu­sion in the list of For­tune 500 com­pa­nies (July 2016 Spe­cial Is­sue) with an over­all sec­tor rank­ing of 12. Akums also re­cently fea­tured in FORBES IN­DIA, March 2017 is­sue.

Look­ing at the Fu­ture

A very im­por­tant part of the com­pany’s fu­ture strate­gies is to fo­cus on new tech­nolo­gies that will re­duce “pa­tient pill bur­den”. Akums will con­tinue to ac­tively pur­sue new tools to man­u­fac­ture for­mu­la­tions with a re­duced dosage fre­quency, for they be­lieve it will not only help econ­o­mize the cost but will have a huge im­pact on pa­tient com­pli­ance, which is still an im­por­tant fac­tor for the fail­ure of a num­ber of ther­a­pies. The world Pharma sec­tor is in a state of tran­si­tion, an ar­ray of deals and as­set swaps have taken place in the re­cent times. Akums is ac­tively look­ing to cap­i­tal­ize on this trend, with a host of part­ner­ships that will al­low us to so­lid­ify our global po­si­tion while of­fer­ing our suite of high qual­ity drug man­u­fac­tur­ing at low costs. Another cat­e­gory is that of nu­tri­tional sup­ple­ments, with In­dia top­ping the charts as one of the most mal­nour­ished pop­u­la­tion in the world, Akums wants to fo­cus on de­vel­op­ing low cost nu­tri­tional sup­ple­ments and food ad­ju­vants which will help in al­le­vi­at­ing key vi­ta­min and min­eral de­fi­cien­cies in the pop­u­la­tion at large. With its NSF-ap­proved Maxcure Nu­travedics Unit, it is in a for­tu­nate po­si­tion to de­liver this. One of its fu­ture strate­gies is to come up with a range of prod­ucts in the vi­ta­min-min­eral, Ayurvedic, li­po­so­mal and plant-de­rived cat­e­gory that are easy to ad­min­is­ter and of­fer no bioavail­abil­ity or taste chal­lenges.

San­deep Jain, Di­rec­tor San­jeev Jain, Di­rec­tor

San­jeev Jain, Di­rec­tor

San­deep Jain, Di­rec­tor

PLANT - 3 In­jecta­bles, Eye/Ear Drops / LVP / PFS

PLANT - 2 Oral Liq­uid Dosage

PLANT - 1 Oral Solid Dosage

PLANT - 4 Hor­monal preparations

PLANT - 5 Cos­metic & Derma

PLANT - 6 Maxcure Nu­travedics Ltd., Ayurvedic, Sup­ple­ment & Nu­tra

PLANT - 8 Peni­cillin

PLANT - 7 Pure & Cure Health­care Ltd., Gen­eral solid Orals, In­jectable, Der­ma­tol­ogy, Liq­uid Oral

PLANT - 9 Cepha

PLANT-11 Cure & Sure Phar­ma­ceu­ti­cals Ltd. Multi Dosage Fa­cil­ity

PLANT-10 Pure & Cure Health­care Ltd. - II Multi Dosage Fa­cil­ity

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