Hindustan Times (Delhi)

The deadly swine flu virus tightens grip

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to a week after.

Influenza A (H1N1)pdm09 virus has been the predominan­t seasonal flu strain worldwide over the past seven years. But in 2017, the influenza A(H3N2) and B viruses became the predominan­t strains, said the WHO.

In India and the Maldives, influenza A(H1N1)pdm09 continues to be the predominan­t strain, with neighbouri­ng Pakistan reporting sporadic cases of influenza A(H3N2) viruses in the recent weeks.

Flu peaks twice a year in India, in July and August and again from October to February. But cases are reported throughout the year.

Getting vaccinatio­n each year reduces symptoms, shortens the duration of the illness and lowers doctors’ visits and flu-related hospitaliz­ations.

But people in India rarely get vaccinated against H1N1.

Each year, the WHO recommends a vaccine that targets the three most deadly flu strains based on flu-tracking data from 143 National Influenza Centres in 113 countries, including India. In the 2017 vaccine, the A/California/7/2009 (H1N1)pdm09 virus has been replaced with an A/Michigan/45/2015 (H1N1)pdm09 virus, while the other two viruses -- the A/Hong Kong/4801/2014 (H3N2) virus; and B/Brisbane/60/2008 – remain the same as last year.

The quadrivale­nt vaccine against four flu viruses includes the B/Phuket/3073/2013 virus.

Vaccinatin­g people at risk is a must in regions where infection continues throughout the year and chances of death from complicati­ons are higher because of late diagnosis, undernouri­shment and poor health infrastruc­ture.

In older persons, vaccinatio­n lowers influenza-related illnesses by 60% and deaths by 70-80%.

Among healthy adults, it reduces illness by 70-90%, and in children, cuts flurelated ICU admission by 74%.

“Now is a good time for people in India to get vaccinated against seasonal flu

On April 12, 2009, a new virus appeared in Mexico and triggered the first pandemic of the 21st century.

Initially called “swine flu” because the new virus shared genes with an influenza virus that infected pigs, it was renamed influenza A/(H1N1) pdm09 by the World Health Organizati­on.

By June 2009, A/(H1N1) pdm09 caused 94,512 confirmed cases and 429 deaths across 135 countries.

Getting flu vaccinatio­n each year reduces symptoms, shortens the duration of the illness and lowers doctors’ visits and flu-related hospitalis­ations because it takes four to six weeks for the protective effects to kick in. Getting vaccinated now will protect people when the flu peaks during the monsoons and again in winter,” said Dr Krishan Chugh, director and head of pediatrics at Fortis Memorial Research Institute, Gurugram.

“Vaccinatio­n not just protects you from infection but also makes you less contagious and reduces the transmissi­on of infection. As more people get vaccinated, the viral load in the community goes down and everyone develop ‘herd immunity’, which makes fewer people vulnerable to serious flu complicati­ons,” said Dr Chugh.

All inactivate­d influenza vaccines contain trace levels of egg protein and should not be given to people with egg protein allergies.

The antigenic shift from A/California/7/2009 (H1N1)pdm09 to A/Michigan/45/2015 (H1N1)pdm09 in 2017 is a minor change and has not led to drug resistance against standard anti-viral medicines used to treat the H1N1 or influenced viral entry into cells, transmissi­on and tissue tropism (cells and tissues that host the virus in the body).

“The Michigan strain has been milder than the California strain in the US and with fewer deaths this year, the trend in India seems to be the same,” said a health ministry official who did not want to be named.

Oseltamivi­r and zanamivir, the antiviral drugs used to treat H1N1, lower the viral-load, shorten the duration and severity of illness and make the patients less contagious.

“Both medicines are manufactur­ed in India and all states have procured drugs. The government does not stockpile the flu vaccine because its life is nine months to a year, but since it is also manufactur­ed in India, there’s no shortfall,” said the ministry official.

 ?? HT FILE ?? Each year, annual influenza outbreaks affect 5-15% of the world’s population, estimates the World Health Organizati­on.
HT FILE Each year, annual influenza outbreaks affect 5-15% of the world’s population, estimates the World Health Organizati­on.

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