KGMU centre finds gene property to increase transplant efficacy

LUCKNOW :King George’s Medical University’s centre for advanced research (CfAR) has successfully related the property of a gene to increase the efficacy of transplants.

The study that was completed in over 5 years, has been conducted in collaboration with the National Cancer Institute, USA by Dr Satyendra Kumar Singh who is working in the stem cell and cell culture unit of the CfAR. It has recently been published in the Cell Stem Cell, a highly reputed journal. The study was done on mouse in collaboration with several departments of the KGMU. “What we intended to see

THE STUDY THAT WAS COMPLETED IN OVER 5 YEARS, HAS BEEN CONDUCTED IN COLLABORATION WITH THE NATIONAL CANCER INSTITUTE, USA

was what is the impact on stem cell maintenance by inhibiting Id1 gene. Its role in the cell proliferation has helped us understand that if the transplant patient is provided a dose of the gene and also the stem cell and the same before being transplanted this will help in increasing the efficacy of transplant,” he said.

The research has suggested that using upstream regulators of the gene Id1 or some more specific inhibitor of Id1 will maintain stemness longer and improve efficacy of bone marrow transplant.

“Now we are working to develop stem cell lab in such a way that this research can reach patients directly as facility for regenerative medicine,” he said. The result will help in bone marrow transplant management as after transplant stem cells encounter proliferation stress in recipient body and exhaust quicker than normal hematopoietic stem cells.

“This is the first known gene that has shown enhanced self-renewal and slowed the aging of hematopoitic stem cells,” he said.