Vitamin B6 supplements may reduce anxiety, depression: Study

Taking high-dose Vitamin B6 supplements may reduce the feelings of anxiety and depression, according to a study.

Scientists at the University of Reading in the UK measured the impact of high doses of Vitamin

B6 on young adults and found that they reported feeling less anxious and depressed after taking the tablets every day for a month.

The study, published in the journal Human Psychopharmacology: Clinical and Experimental, provides valuable evidence to support the use of supplements thought to modify levels of activity in the brain for preventing or treating mood disorders. "The functioning of the brain relies on a delicate balance between the excitatory neurons that carry information around and inhibitory ones, which prevent runaway activity, said study lead author David Field, from the University of Reading.

"Recent theories have connected mood disorders and some other neuropsychiatric conditions with a disturbance of this balance, often in the direction of raised levels of brain activity, Field said. The researchers noted that vitamin B6 helps the body produce a specific chemical messenger that inhibits impulses in the brain, and the study links this calming effect with reduced anxiety among the participants.

While previous studies have produced evidence that multivitamins can reduce stress levels, few studies have been carried out into which particular vitamins contained within them drive this effect.

The latest study focused on the potential role of Vitamins B6, which is known to increase the body's production of GABA (Gamma-Aminobutyric Acid), a chemical that blocks impulses between nerve cells in the brain.

In the study, more than 300 participants were randomly assigned either vitamin B6 or B12 supplements approximately 50 times the recommended daily allowance or a placebo, and took one a day with food for a month.

The study showed that Vitamin B12 had little effect compared to placebo over the trial period, but Vitamin B6 made a statistically reliable difference. Raised levels of GABA among participants who had taken vitamin B6 supplements were confirmed by visual tests carried out at the end of the trial, supporting the hypothesis that B6 was responsible for the reduction in anxiety.

Subtle but harmless changes in visual performance were detected, consistent with controlled levels of brain activity, the researchers said. "Many foods, including tuna, chickpeas and many fruits and vegetables, contain vitamin B6. However, the high doses used in this trial suggest that supplements would be necessary to have a positive effect on mood," Field said.

"It is important to acknowledge that this research is at an early stage and the effect of vitamin B6 on anxiety in our study was quite small compared to what you would expect from medication.

"However, nutrition-based interventions produce far fewer unpleasant side effects than drugs, and so in the future people might prefer them as an intervention," he added.