In­hibit the Cal­pain to climb the moun­tain

SP's MAI - - TECHNOLOGY -

Sci­en­tists at De­fence In­sti­tute of Phys­i­ol­ogy and Al­lied Sci­ences (DIPAS), De­fence Re­search and De­vel­op­ment Or­gan­i­sa­tion (DRDO) have iden­ti­fied a novel mech­a­nism for throm­bo­sis in­duced by high al­ti­tude en­vi­ron­ment. The throm­bo­sis de­vel­oped at re­gions like Si­achin Glaciers may lead to life-threat­en­ing events such as pul­monary em­bolism, stroke, and limb am­pu­ta­tion.

Di­rec­tor, DIPAS, Dr Shashi Bala Singh, de­scribes this work as a key step to­wards un­der­stand­ing such dis­or­ders. The study by the Ge­nomics lab, DIPAS, led by Dr Zahid Ashraf us­ing pro­teomic anal­y­sis of platelets and an­i­mal mod­els el­e­gantly demon­strated that en­hanced ac­tiv­ity of an en­zyme ‘cal­pain’ sig­nif­i­cantly con­trib­utes to throm­bo­sis un­der hy­poxic con­di­tions. In­ter­est­ingly, the in­ves­ti­ga­tions on the soldiers who de­vel­oped throm­bo­sis while serv­ing at ex­treme al­ti­tude also re­vealed an in­creased ac­tiv­ity of cal­pain con­firm­ing the rel­e­vance of the novel pre­clin­i­cal find­ings for clin­i­cal ap­pli­ca­tions.

The find­ings have been pub­lished in cur­rent Fe­bru­ary 20, is­sue of med­i­cal weekly Blood, of­fi­cial jour­nal of Amer­i­can So­ci­ety of He­ma­tol­ogy with ed­i­to­rial com­men­tary. The novel find­ings could lead to de­vel­op­ment of ther­a­peu­tics aimed at specif­i­cally pre­vent­ing or treat­ing throm­botic dis­or­ders in­duced at high al­ti­tude re­gions. The sim­ple bio­an­a­lytic as­say of ‘cal­pain’ could be de­vel­oped for an early di­ag­no­sis test for such dis­or­ders.

In­ter­est­ingly, Air Mar­shal D.P. Joshi, Di­rec­tor Gen­eral Armed Forces Med­i­cal Ser­vices, has com­mis­sioned a study on epi­demi­ol­ogy of ve­nous throm­botic dis­or­ders in low­lan­ders at high al­ti­tude. Ma­jor Gen­eral Velu Nair, Dean AFMC, Pune is su­per­vis­ing this on­go­ing mul­ti­cen­tric study in col­lab­o­ra­tion with DIPAS. A co­hort of more than 600 soldiers is be­ing stud­ied lon­gi­tu­di­nally dur­ing their in­duc­tion and sub­se­quent post­ing at ex­treme al­ti­tudes. SP

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