‘ WOMEN WITH BREAST CANCER CAN SKIP CHEMOTHERAPY’

Chicago, June 3: Some 70 percent of women with early- stage breast cancer and an intermediate risk of cancer recurrence can safely skip chemotherapy after their tumors have been removed, U. S. researchers said on Sunday.

“This is a major finding,” said Dr. Larry Norton, a breast cancer expert at Memorial Sloan Kettering Cancer Center in New York, who helped organize the governmentfunded study more than a decade ago.

“It means that maybe 100,000 women in the United States alone do not require chemotherapy,” Norton said.

The research, presented at the American Society of Clinical Oncology ( ASCO) meeting in Chicago, studied how to treat women with earlystage breast cancer that responds to hormone therapy.

Women were deemed to have a medium level risk of the cancer coming back based on a 21- gene panel known as Oncotype DX from Genomic Health ( GHDX. O). The test predicts the likelihood of cancer recurrence within 10 years. Those who score low on the test - from zero to 10 - are already told to skip chemotherapy after their tumors are removed and they receive hormone therapy. Those who score high — 26 to 100 — receive both hormone therapy and chemotherapy.

he study, dubbed TAILORx, was also published in the New England Journal of Medicine. It involved more than 10,000 women with breast cancer that had not spread to nearby lymph nodes and whose tumors respond to hormone therapy and test negative for the HER2 gene.