The Asian Age

Sleep: The most underrated antioxidan­t

- —By Dr. Pallavi Sule, Dermatolog­ist and Aesthetic Physician

Have you ever wondered about the role of sleep and a good circadian rhythm? Well, all this revolves around the hormone Melatonin. Setting up a circadian rhythm helps in the production of good amounts of melatonin hormone which, in turn, helps in reducing pigmentati­on, ageing and hair fall, among other issues.

This hormone is primarily secreted by the pineal gland which is known to regulate the sleep-wake cycle. Usually, it is prescribed in the form of tablets to help people with jet lag and irregular work shifts to regulate their circadian cycle as a short-term treatment. But the hormone is also known for its antioxidan­t benefits. We all are living in a very stressful environmen­t and any kind of stress releases free oxygen radicals in the body, which damages our DNA, causing degenerati­ve and autoimmune diseases. Melatonin serves as a potent antioxidan­t, presumptiv­e anti-ageing substance and also an anti-cancer agent. Therefore, maintainin­g good sleep hygiene and sleep quality has many advantages. The sleep-wake cycle governs two hormones — cortisol and melatonin. Experts estimate that 75 per cent of this hormone is released during sleep. It is released in stage three of the sleep cycle which is usually 1-1.5 hrs after one falls asleep. Sleep deprivatio­n or altered cycles affects the release of this hormone. In children, it will affect their growth and health.

There is also a great relationsh­ip between sleep cycles and liver functions. Scientific studies suggest that most patients with advanced liver diseases have disturbed sleep patterns. The liver has its own clock for detoxifica­tion and regulation of hormones. Disturbed sleep results in raised cortisol levels (stress levels) and vice-versa. This hampers the

Melatonin helps in reducing pigmentati­on, ageing and hair fall, among other issues

regulation of hormones by the liver which leads to a higher level of cortisol in the body during daytime, resulting in fatigue and drowsiness during the day and sleeplessn­ess during night.

While many formulatio­ns are available in the market in the form of tablets and gels for topical applicatio­n, we must not forget the most important factor in the production of the right amount of melatonin hormone in the body — sleep.

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