Many animal species may be vulnerable to Covid-19

Scientists say marine mammals like gray whales and bottlenose dolphins risk catching virus

Los Angeles, Aug. 23: Humans are not the only species facing a potential threat from the Coronavirus, according to a new study which says several critically endangered primates such as the Western lowland gorilla, Sumatran orangutan, and Northern white-cheeked gibbon may be susceptible to infection with the virus.

Scientists, including those from the University of California (UC) — Davis in the US, used genomic analysis to compare the structure of the ACE2 receptor protein which the Coronavirus uses to enter cells across 410 different species of vertebrates, including birds, fish, amphibians, reptiles and mammals. According to the study, published in the journal PNAS, ACE2 is normally found in many different types of cells and tissues, including the cells lining the outer layer of the nose, mouth, and lungs. Of the amino acid building blocks which make up ACE2, the scientists said 25 of these molecules in the protein are important for the Coronavirus, SARS-CoV-2, to bind and gain entry into human cells.

In the study, they used the sequence of these 25 amino acid molecules, assessed how they interact with each other, and modelled its predicted protein structure. Using this model, the researchers evaluated how many of the 25 amino acids are found in the ACE2 protein of the different species.

“Animals with all 25 amino acid residues matching the human protein are predicted to be at the highest risk for contracting SARS-CoV-2 via ACE2,”said Joana Damas, a co-author of the study from UC Davis.

“The risk is predicted to decrease the more the species’ ACE2 binding residues differ from humans,” Damas said. According to the researchers, about 40 per cent of the species potentially susceptible to SARS-CoV-2 are classified as “threatened” by the International Union for Conservation of Nature, and may be especially vulnerable to human-to-animal transmission.

“The data provide an important starting point for identifying vulnerable and threatened animal populations at risk of SARSCoV-2 infection,” said Harris Lewin, lead author of the study from UC Davis. “We hope it inspires practices that protect both animal and human health during the pandemic,” Lewin

said.

The study noted that several critically endangered primate species, such as the Western lowland gorilla, Sumatran orangutan and Northern whitecheeked gibbon, are predicted to be at very high risk of infection by the Coronavirus. It said marine mammals such as gray whales and bottlenose dolphins, as well as Chinese hamsters are also at high risk of catching the virus. Among domestic animals, the scientists said cats, cattle, and sheep were found to have a medium risk, while dogs, horses, and pigs have low risk for the virus binding to their ACE2 receptors.

“These species represent an opportunity for spillover of SARS-CoV-2 from humans to other susceptible animals. Given the limited infectivity data for the species studied, we urge caution not to over-interpret the predictions of the present study,” the scientists wrote. They cautioned that it is yet to be determined how this relates to infection and disease risk, but said for the species with known infectivity data, this correlation is high.

THERE ARE documents that show how children were taught to shift to online schooling. And instructions, complete with diagrams, on how to make a mask from a handkerchief. Several hundred objects have been collected so far, after a call went out to residents.