Say goodbye to ailments with venom

The newly found classes of venomous drugs have the potential to treat chronic pain, diabetes and autoimmune diseases, etc

Venomous reptiles, bugs and marine life have notorious reputations as dangerous, sometimes life-threatening creatures. But in a paper in the current issue of Science, first author Mandë Holford, an associate professor of chemistry and biochemistry at The Graduate Center of The City University of New York (GC/CUNY) and Hunter College, details how technology and a growing understanding of the evolution of venoms are pointing the way toward entirely new classes of drugs capable of treating diabetes, autoimmune diseases, chronic pain, and other conditions.

According to Holford and her colleagues, venomous species account for more than 15 percent of the Earth’s documented biodiversity, and they can be found in virtually all marine and terrestrial habitats. Still, researchers have studied very few venoms, because until recently they lacked the appropriate technology for analysing the tiny amounts of venom that can be extracted from these mostly small species.

But innovations in omics are allowing researchers to uncover evolutionary changes and diversification among specific venomous species that could prove useful in developing new drugs capable of precisely targeting and binding to molecules that are active in certain human diseases.

“Knowing more about the evolutionary history of venomous species can help us make more targeted decisions about the potential use of venom compounds in treating illnesses,” said Holford. “New environments, the development of venom resistance in its prey, and other factors can cause a species to evolve in order to survive. These changes can produce novel compounds – some of which may prove extremely useful in drug development.”

To date, only six Food and Drug Administration-approved, venom-derived drugs have been developed as a result of modern-day research, but Holford and her colleagues believe greater investment in venom research could yie ld therapies for currently untreatable diseases as well as improved therapeutic options.