These cells rewire, repair brain while we are asleep

Researchers have found that immune cells called microglia, which play an important role in reorganising the connections between nerve cells, fighting infections, and repairing damage, are also primarily active while we sleep. Microglia serve as the brain’s first responders, patrolling the brain and spinal cord and springing into action to stamp out infections or gobble up debris from dead cell tissue.

“This research shows that the signals in our brain that modulate the sleep and awake state also act as a switch that turns the immune system off and on,” said study lead author Ania Majewska, Professor at University of Rochester in the US.

In previous studies, Majewska’s lab has shown how microglia interact with synapses, the juncture where the axons of one neuron connects and communicates with its neighbours.

The microglia help maintain the health and function of the synapses and prune connections between nerve cells when they are no longer necessary for brain function. For the findings, researchers conducted the study on mice.

The current study points to the role of norepinephrine, a neurotransmitter that signals arousal and stress in the central nervous system. This chemical is present in low levels in the brain while we sleep, but when production ramps up it arouses our nerve cells, causing us to wake up and become alert.

The study showed that norepinephrine also acts on a specific receptor, the beta2 adrenergic receptor, which is expressed at high levels in microglia. When this chemical is present in the brain, the microglia slip into a sort of hibernation.