ORaL an­TIbI­OTIcS may uP RISk Of kId­ney STOneS

The Sunday Guardian - - Covert - IANS

NEW YORK: Chil­dren and adults treated with oral an­tibi­otics may have a higher risk of de­vel­op­ing kid­ney stones, ac­cord­ing to a new study.

The find­ings, pub­lished in Jour­nal of the Amer­i­can So­ci­ety of Nephrol­ogy, sug­gested that the strong­est risks ap­peared at younger ages and among pa­tients most re­cently ex­posed to an­tibi­otics.

“The over­all preva­lence of kid­ney stones has risen by 70 per cent over the past 30 years, with par­tic­u­larly sharp in­creases among ado­les­cents and young women,” said lead au­thor Gre­gory E. Tasian from the Chil­dren’s Hospi­tal of Philadelphia (CHOP).

Ac­cord­ing to the re­searchers, kid­ney stones were pre­vi­ously rare in chil­dren.

“The rea­sons for the in­crease are un­known, but our find­ings sug­gest that oral an­tibi­otics play a role, es­pe­cially given that chil­dren are pre­scribed an­tibi­otics at higher rates than adults,” said co-au­thor Michelle Den­burg from CHOP.

For the study, the team an­a­lysed prior an­tibi­otic ex­po­sure for nearly 26,000 pa­tients with kid­ney stones, com­pared to nearly 260,000 con­trol sub­jects. They found that five classes of oral an­tibi­otics, oral sul­fas, cephalosporins, flu­o­ro­quinolones, ni­tro­fu­ran­toin, and broad­spec­trum peni­cillins , were as­so­ci­ated with a di­ag­no­sis of kid­ney stone dis­ease.

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