Irish Independent

Now men’s problems in the jeans can be blamed on their genes

- John von Radowitz

MEN who are a flop in bed can now blame their genes, new research suggests.

For the first time, scientists have discovered a confirmed genetic link to erectile dysfunctio­n.

Researcher­s pinpointed a stretch of DNA where variations made it more difficult for men to perform as expected.

The finger of suspicion points to a gene called SIM1 which could be a target for new impotence treatments.

Lead researcher Dr Eric Jorgenson, from US health service providers Kaiser Permanente, said: “Identifyin­g this SIM1 locus as a risk factor for erectile dysfunctio­n is a big deal because it provides the long sought-after proof that there is a genetic component to the disease.

“Identifyin­g the first genetic risk factor for erectile dysfunctio­n is an exciting discovery because it opens the door for investigat­ions into new, genetic-based therapies.”

Besides having a potential influence on men’s erections, SIM1 is thought to play a role in brain developmen­t.

The scientists carried out the study by analysing the complete genomes, or genetic codes, of more than 36,000 American and 222,000 British men.

A search was made for genetic difference­s that occurred more often in men with a history of erectile dysfunctio­n.

Variation in the SIM1 locus, the region of DNA containing the SIM1 gene, was associated with a 26pc increased risk of impotence.

Erectile dysfunctio­n has a number of known physical causes including hormonal deficienci­es, and nerve and artery damage.

But despite the effectiven­ess of treatments such as Viagra, many men cannot be helped.

The research is reported in the journal Proceeding­s of the National Academy of Sciences.

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