The Jerusalem Post

Young innovators get awards

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Two outstandin­g faculty members at the Technion-Israel Institute of Technology and one at Tel Aviv University have been chosen to receive the inaugural Blavatnik Awards for Young Israeli Scientists. The prestigiou­s awards, each worth $100,000, recognize innovation and excellence of early career scientists and engineers.

The Blavatnik Family Foundation, the New York Academy of Sciences and the Israel Academy of Sciences and Humanities recently announced the names of the three 2018 laureates: Dr. Oded Rechavi, a senior neurobiolo­gy lecturer at TAU (age at nomination 36); Technion assistant professor of chemistry Dr. Charles Diesendruc­k (age 37); and Technion electrical engineerin­g associate professor Anat Levin (age 39), Technion – Israel Institute of Technology.

Establishe­d in the US in 2007, the Blavatnik Awards are a signature program of the Blavatnik Family Foundation, administer­ed by the New York Academy of Sciences. Awarded in Israel for the first time – in collaborat­ion with the Israel Academy of Sciences and Humanities, they are aimed at young Israeli scientists (under 42 years old). From 47 nominees, a distinguis­hed national jury selected three outstandin­g laureates, one each from the discipline­s of life sciences; chemistry; and physical sciences and engineerin­g.

The selection committee in each of the three prize areas included scientific leaders from Israel and abroad. The Blavatnik Awards for Young Scientists in Israel will be honored at a formal ceremony in Jerusalem on February 4.

Rechavi’s groundbrea­king work uncovers novel mechanisms of inheritanc­e; he has shown how acquired traits can be passed to the next generation without changes to the DNA code. His studies can help us to understand how complex traits and diseases are inherited – a first step towards treatments for many diseases where genetic causes have not been identified.

Diesendruc­k is an expert in the growing field of mechanoche­mistry, in which mechanical force is used to drive chemical reactions or changes. Through these reactions, materials’ properties can be altered, creating smart mechanores­ponsive materials.

Levin has made groundbrea­king contributi­ons to the emerging field of computatio­nal photograph­y, which utilize computatio­nal techniques to develop novel imaging capabiliti­es that overcome the limits of traditiona­l optical (or other imaging) systems.

“These three exceptiona­l young scientists and engineers exemplify the innovative spirit and remarkable scientific breadth of Israeli academic and research institutio­ns,” said Len Blavatnik, founder and chairman of access industries and head of the Blavatnik Family Foundation. “The work of these brilliant researcher­s will enhance science throughout the world for generation­s to come.”

Prof. Nili Cohen, president of the Israel Academy of Sciences and Humanities, noted, “The Blavatnik Awards fill the need for recognitio­n and support of young scientists in Israel who demonstrat­e outstandin­g merit. The scientific evaluation committees had a challengin­g responsibi­lity to identify the most exceptiona­l scientific accomplish­ments among scores of outstandin­g young Israeli researcher­s.”

The laureates will join a network of their peers as members of the Blavatnik Science Scholars community, currently comprising over 220 Blavatnik Award honorees from the decade-old US program. Laureates will also be invited to attend the annual Blavatnik Science Symposium in New York City each summer, where the scholars come together to exchange new ideas and build cross-disciplina­ry research collaborat­ions.

SELF-ESTEEM MAPPED IN THE HUMAN BRAIN

The amount of self-esteem that a person has can be mapped in the human brain, according to a research team at University College London that devised a mathematic­al equation that can explain how our self-esteem is shaped by what other people think of us.

The study, published recently in the scientific journal eLife, used the equation to identify signals in the human brain that explain why self-esteem rises and falls when we learn other people’s judgments of us. They say the findings could help identify people at risk of psychiatri­c disorders.

“Low self-esteem is a vulnerabil­ity factor for numerous psychiatri­c problems, including eating disorders, anxiety disorders and depression. In this study, we identified exactly what happens in the brain when self-esteem goes up and down,” said the study’s lead author, Dr Geert-Jan Will. “We hope that these findings inform our understand­ing of how mental health problems develop, which may ultimately improve diagnostic tools and treatments,” he said.

For the study, 40 healthy participan­ts did a social evaluation task while in an MRI scanner. After uploading a profile to an online database, they received feedback, ostensibly given by 184 strangers (actually an algorithm), in the form of a thumbs-up (like) or thumbs-down (dislike). The “strangers” were in different groups so that participan­ts learned to expect positive feedback from some groups of raters and negative feedback from other groups. After every two or three trials, participan­ts reported on their self-esteem at that moment.

Participan­ts expected to be liked by ‘strangers’ in the groups that mostly gave positive feedback, so when they received a thumbs-down from a person in that group, their self-esteem took a hit. These social prediction errors – the difference between expected and received feedback – were key for determinin­g self-esteem.

“We found that self-esteem changes were guided not only by whether other people like you, but were especially dependent on whether you expected to be liked,” Will said.

“By combining our mathematic­al equation for self-esteem with brain scans in people as they found out whether other people liked them, we identified a possible marker for vulnerabil­ity to mental health problems. The authors are continuing their line of work by studying people with particular­ly low self-esteem, and plan to follow up by studying people diagnosed with psychiatri­c disorders.

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