Studies in ‘healthy elderly’ aim to prevent Alzheimer’s

Cholera cases soar in Yemen

PHOENIX, Oct 2, (Agencies): It may be too late to stop Alzheimer’s in people who already have some mental decline. But what if a treatment could target the very earliest brain changes while memory and thinking skills are still intact, in hope of preventing the disease? Two big studies are going all out to try.

Clinics throughout the United States and some other countries are signing up participants – the only studies of this type enrolling healthy older people.

“The excitement in the Alzheimer’s field right now is prevention,” said Dr Eric Reiman, executive director of the Banner Alzheimer’s Institute in Phoenix, which is leading the work.

Science so far has failed to find a drug that can alter the progression of Alzheimer’s, the most common form of dementia; 146 attempts have failed over the last decade, a recent industry report found. Even drugs that help remove the sticky plaques that clog the brains of people with the disease have not yet proved able to stave off mental decline.

It may be that they were tried too late, like lowering cholesterol after someone has suffered a heart attack whose damage can’t be undone, Reiman said.

“What we have been learning, painfully, is that if we really want to come up with therapies that will modify the disease, we need to start very, very, very early,” said Dr Eliezer Masliah, neuroscience chief at the National Institute on Aging.

His agency is funding the prevention studies with the Alzheimer’s Association, several foundations, and Novartis and Amgen, makers of two experimental drugs being tested.

Symptoms

The goal is to try to block the earliest steps of plaque formation in healthy people who show no symptoms of dementia but are at higher risk for it because of age and a gene that makes it more likely.

To participate, people must first join GeneMatch, a confidential registry of folks interested in volunteering for various Alzheimer’s studies who are ages 55 to 75 and have not been diagnosed with any mental decline.

They are checked for the APOE4 gene, which doesn’t destine someone to develop Alzheimer’s but raises that risk. About one in four people have one copy of the gene and about 2 percent have two copies, one from each parent.

More than 70,000 people have signed up since the registry began three years ago, said Jessica Langbaum, one of the Banner study leaders.

“Most of them have been touched by the disease personally,” either by having a family member or close friend with it, she said.

Langbaum’s 67-year-old mother, Ivy Segal, gave a DNA sample through a cheek swab and joined the registry in August. Her father was a patient at Banner and died of Alzheimer’s in 2011 at age 87. Watching him go from a mild-mannered man whose smile could light up a room to what he was like when he died was devastating, she said.

Being in GeneMatch doesn’t necessarily mean you’ll find out if you have the gene – folks with and without it may be contacted about various studies. But to be in one of the two prevention studies, people must agree to learn their APOE4 status and have at least one copy of the gene.

Participants get periodic brain scans and memory and thinking tests every six months. They are given experimental drugs or placebo versions of them for several years.

One study is enrolling people with two copies of the gene. They are given either shots every few months of a drug intended to help the immune system clear plaque from the brain or daily pills of a drug intended to prevent first steps of plaque formation, or placebo versions of these experimental treatments.

DUBAI:

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Suspected cholera cases have nearly tripled in the past three months in Hodeida, the Yemeni port city on the front line between a pro-government alliance and rebels, Save the Children said Tuesday.

“Health facilities supported by Save the Children across (Hodeida) governorate recorded a 170 percent increase in the number of suspected cholera cases, from 497 in June to 1,342 in August,” a report by the London-based NGO said.

In late July, “airstrikes resulted in the damage of a sanitation facility and water station that supplies Hodeida with most of its water”, the report said.

“After this incident, suspected cholera cases almost doubled” between July and August in health centres supported by the NGO, it said.

The United Nations and World Health Organization have warned Yemen faces a third cholera epidemic as autumn rains have increased the risk of infection.

Yemen has already been hit by two major cholera outbreaks in the past two years.