Ebola shots in Uganda
‘Racial gap’ seen in US infant deaths after IVF
NEW YORK, Oct 19, (AP): Black-white disparities exist in fertility medicine, reflected in life-and-death outcomes for babies, according to a large study of US births.
The study, published Wednesday in the journal Pediatrics, is the broadest look yet at racial gaps for women who use in vitro fertilization, fertility drugs or other fertility treatments. Researchers found higher death rates for infants born to Black women who used such treatments than white women who did the same - a gap that is much wider than in babies born without those treatments.
Infant deaths are rare in the US, and the reasons for poor outcomes are unclear. Researchers saw racial gaps even after adjusting for age, diabetes, obesity, smoking and other maternal risk factors.
The steep cost of IVF and the scarcity of insurance coverage means women getting fertility care are wealthier on average.
The findings suggest women seeking fertility treatment are not protected from racism despite their relative affluence, said Dr. Cynthia GyamfiBannerman, head of obstetrics and gynecology at the University of California San Diego medical school.
“These women are still experiencing the same racism that might be causing poor outcomes in other pregnancies,” said Gyamfi-Bannerman, who was not involved in the study. “We all need to pay more attention and see how we can find a solution.”
Black women who use fertility treatments may not be getting the highest quality care during pregnancy and after childbirth, said Dr. Michael A. Thomas, who will become the first Black president of the American Society for Reproductive Medicine next week.
“The IVF patients, they work so hard to get there that they don’t allow anything to stand in the way of that baby getting a good outcome,” said Thomas, who was not involved in the study. “But is the Black patient getting that same high-level, priority, concierge treatment?”
The researchers thought women using fertility treatments might see less racial disparity in birth outcomes.
Fertility
“We were a bit surprised that this disparity was actually larger than in the general population,” said Dr. Sarka Lisonkova of the University of British Columbia in Vancouver, who led the research.
Her team analyzed data for more than 7 million US births in 2016 and 2017, including more than 93,000 births resulting from fertility treatments.
They looked only at single births, which carry less risk than twin or other multiple births. Household income was not analyzed because it was not available in the data.
Deaths within four weeks after birth were four times higher in babies born to Black mothers who used IVF compared with white mothers who used IVF. Among babies born without fertility treatments, infant deaths were two times higher for Black moms compared with white moms.
Similar disparities existed for Hispanic and Asian mothers who had fertility treatments, but the gaps were less pronounced. There were too few American Indian and Alaska Native women using fertility treatments in the study to analyze their birth outcomes.
White women were much more likely than other groups to use fertility treatments. Of the 69,778 white mothers who used fertility treatments over the two years of the study, 227 infants died. Of the 4,669 Black mothers who used fertility treatments, 68 infants died.
The findings should not deter women from pursuing a family, Lisonkova said.
“There are countless women who have had fantastic pregnancies that started with medically assisted reproduction,” Lisonkova said. But because pregnancies to older women and those conceived with fertility treatment have worse outcomes than spontaneously conceived pregnancies, she encouraged women who want children to think about starting a family when they are “relatively young.”
“I know there are pressures to have your education, have your job and then have your family, but I think they’re both important,” she said. “And they can be combined in a way that women do not have to choose.”
Strain
Experimental Ebola vaccines will be deployed in Uganda in about “two weeks,” a World Health Organization official said Wednesday, as the East African country carried out tough preventive measures that include a lockdown in the Ebola-hit areas.
Potentially hundreds of thousands of trial vaccine doses will buttress a response effort that still must focus on tracing Ebola contacts and community engagement, Dr. Yonas Tegegn Woldemariam, the WHO representative in Uganda, told The Associated Press.
“We are getting closer and closer to deploying vaccines,” he said. “This is a study. This is just another tool that we are going to try.”
Vaccines developed by the US-based Sabin Vaccine Institute and Oxford University “are ready to be shipped” to Uganda, which is finalizing protocols for the study before the National Drug Authority issues import permits, he said.
The Sudan strain of Ebola, for which there’s no proven vaccine, is circulating in Uganda. Ebola, which manifests as a viral hemorrhagic fever, has infected at least 60 people and killed 24. The official figures don’t include people who likely died of Ebola before the outbreak was confirmed. Victims include five health workers.
The Oxford vaccine is being produced by the Serum Institute of India, which has indicated it can eventually make hundreds of thousands of doses available, according to Yonas, who is closely following Uganda’s Ebola response.
Uganda declared an outbreak of Ebola on Sept. 20, several days after the contagious disease began spreading in a rural farming community. A lockdown and nighttime curfew measures are now in place in the outbreak’s epicenter, about 150 kilometers (90 miles) west of the capital, Kampala.
Ebola is spread by contact with bodily fluids of an infected person or contaminated materials. Symptoms include fever, vomiting, diarrhea, muscle pain and at times internal and external bleeding.
Scientists don’t know the natural reservoir of the virus, but they suspect the first victim in an Ebola outbreak gets infected through contact with an infected animal or eating its raw meat. Ugandan officials are still investing the source of the current outbreak.
Uganda has had multiple Ebola outbreaks, including one in 2000 that killed more than 200 people. The 2014-16 Ebola outbreak in West Africa killed more than 11,000 people, the disease’s largest death toll ever.
Ebola was discovered in 1976 in two simultaneous outbreaks in South Sudan and Congo, where it occurred in a village near the Ebola River after which the disease is named.
Ugandan authorities on Saturday imposed a travel lockdown on two Ebola-hit districts as part of efforts to stop the spread of the contagious disease.
The measures announced by President Yoweri Museveni mean residents of the central Ugandan districts of Mubende and Kassanda can’t travel into or out of those areas by private or public means. Cargo vehicles and others transiting from Kampala, the capital, to southwestern Uganda are still allowed to operate, he said.