Gel-B boosts gut bacteria growth compared to prebiotics
BOSTON, Nov 3: Gelesis Holdings Inc. (NYSE: GLS) (“Gelesis” or the “Company”) the maker of Plenity for weight management, has released new data at Obesity Week in San Diego. The study investigated how an oral superabsorbent hydrogel (Gel-B or GS200) increases in comparison to two prebiotics, inulin, and psyllium is a bacteria associated with thickened mucosal lining of the gut, that encourages improved gut barrier function, and lean body mass.
Gelesis, along with collaborators at Humanitas University in Milan, Italy, also examined how Gel-B supports growth of in an animal model. The group found that A. grows in the presence of Gel-B as early as two weeks post-treatment. The study provides further support of the hypothesis that the physical structure of the oral superabsorbent hydrogels and its specific mechanical properties (e.g, level of elasticity) provides the environment to supports the growth of A. muciniphila.
“These data are an important step forward in understanding how oral superabsorbent hydrogels induce beneficial changes to the microbiome. We are looking forward to conducting further studies in this area to understand how these changes will translate to humans,” said Elaine Chiquette, Gelesis Chief Scientific Officer.
Management
Gelesis Holdings Inc. (NYSE: GLS) (“Gelesis”) is a consumer-centered biotherapeutics company and the maker of Plenity®, which is inspired by nature and FDA cleared to aid in weight management. Our first-of-their-kind non-systemic superabsorbent hydrogels are made entirely from naturally derived building blocks. They are inspired by the composition and mechanical properties of raw vegetables, taken by capsule, and act locally in the digestive system, so people feel satisfied with smaller portions. Our portfolio includes Plenity® and potential therapies in development for patients with Type 2 Diabetes, Non-alcoholic Fatty Liver Disease (NAFLD)/Non-alcoholic Steatohepatitis (NASH), and Functional Constipation. For more information, visit gelesis.com, or connect with us on Twitter @GelesisInc.
Plenity® is indicated to aid weight management in adults with excess weight or obesity, a Body Mass Index (BMI) of 25-40 kg/m², when used in conjunction with diet and exercise.
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