The Star Malaysia

The UAE and China have launched a phase three clinical trial of a vaccine in the race to find a solution to Covid-19.

China and uae launch phase three of human trial for Covid-19 vaccine

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China reached an important new level of vaccine developmen­t with the start of the phase three clinical trial of an inactivate­d vaccine candidate against Covid-19 in the United Arab Emirates.

It is the first vaccine of its kind to reach a late-stage, mass-scale human trial, according to China National Biotec Group (CNBG).

The Institute of Microbiolo­gy of the Chinese Academy of Sciences said in a statement on Tuesday that Chinese authoritie­s approved the phase one trial of the nation’s first recombinan­t protein vaccine against Covid-19 on Friday.

The recombinan­t protein vaccine is the nation’s third type of vaccine, after an adenovirus vector vaccine and the inactivate­d vaccine, to enter clinical trials in China, the statement said.

The Wuhan and Beijing units of the CNBG each developed an inactivate­d vaccine candidate, and one or the other of these vaccine candidates were tested on a group of 2,240 people during phase one and two clinical trials, the CNBG said.

The Wuhan vaccine was found to be effective and safe, with no serious adverse effects, according to trial results published on June 16.

Various dosages and timings were tried.

Those who received two doses at an interval of 28 days, all in the 18 to 59 age group, tested positive for neutralisi­ng antibodies against the coronaviru­s.

The Beijing vaccine’s test results will be published on Sunday, the CNBG said on Tuesday.

The UAE’s Health and Prevention ministry has approved the phase three trials, though it is unclear which vaccine will be used.

As for the recombinan­t protein vaccine, the Institute of Microbiolo­gy said it has been shown to be safe and effective in animal tests and is easy to mass produce.

China’s recombinan­t protein vaccine candidate has been jointly developed by the Institute of Microbiolo­gy and Anhui Zhifei Longcom Biopharmac­eutical.

The United States, Israel, Japan, Argentina, Thailand and other countries are working on similar recombinan­t vaccines, according to the World Health Organisati­on.

Unlike an inactivate­d vaccine, which uses a whole dead targeted virus, and a vector vaccine, which uses a chemically weakened second virus as a carrier, a recombinan­t protein vaccine uses only part of the targeted virus to trigger a protective immune response.

This type of vaccine is known to provide very strong protection and is safe even for people who are immuno-compromise­d, the United States’ National Institutes of Health said.

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