Blood test to detect autism

RESEARCHERS in the US have managed to accurately predict whether a child is on the autism spectrum by means of a simple blood test, based on an algorithm that analyses levels of specific molecules, linked to autism spectrum disorder, present in blood samples.

This groundbreaking first could pave the way for early diagnosis of ASD (autistic spectrum disorder).

The algorithm developed by scientists at the Rensselaer Polytechnic Institute in New York measures 24 metabolites found in the blood and which is capable of predicting – in 97% of cases – whether a person is affected by autism and to what extent.

Previous studies investigating the diagnosis ASD by blood test have focused on one individual biomarker, metabolite or gene in identifying the disease.

However, such studies were not found to be statistically significant, the researchers report.

The algorithm was based on mathematical and statistical data gathered from blood samples taken from 149 patients ( about half of whom were on the autism spectrum) to help them understand and analyse the various biological phenomena at play. The data gave scientists valuable insight into the interactions between molecules that control cell function.

The research highlights two biological processes linked to the disease: the modification of DNA and a drop in the production of a powerful antioxidant called glutathione, which reduces oxidative stress.

The study could help improve early diagnosis of ASD, which is currently diagnosed in most children after age four. – AFPRelaxnews