Could daugh­ter’s cancer risk be af­fected by fa­ther’s age at birth?

Daily Trust - - HEALTH -

Afather’s age at the time of his daugh­ter’s birth may af­fect her risk for breast, ovar­ian and en­dome­trial cancer in adult­hood, a new study sug­gests. Re­searchers ex­am­ined data from more than 133,000 women who took part in a study of Cal­i­for­nia teach­ers and ad­min­is­tra­tors. Be­tween 1995 and 2010, more than 5,300 of the women were di­ag­nosed with breast cancer, 515 with ovar­ian cancer and more than 1,100 with en­dome­trial cancer -- cancer of the lin­ing of the uterus.

Com­pared to women born to fa­thers aged 25 to 29, those born to fa­thers younger than age 20 were 35 per­cent more likely to de­velop breast cancer and nearly two times more likely to de­velop ovar­ian cancer.

On the other hand, those born to fa­thers aged 30 to 34 had a 25 per­cent higher risk of en­dome­trial cancer.

The study was sched­uled for pre­sen­ta­tion Mon­day at the Amer­i­can As­so­ci­a­tion for Cancer Re­search (AACR) an­nual meet­ing, held in San Diego. Stud­ies should be viewed as pre­lim­i­nary un­til pub­lished in a peer-re­viewed jour­nal.

Pre­vi­ous re­search has looked at how par­ents’ age at the time of birth af­fects a child’s health. But few have fo­cused on the link be­tween par­ents’ age and a daugh­ter’s risk of these three hor­monere­lated can­cers in adult­hood, ac­cord­ing to the City of Hope re­searchers.

“Our find­ings in­di­cate that parental age, es­pe­cially pa­ter­nal age, at con­cep­tion ap­pears to be as­so­ci­ated with a wide range of ef­fects on the health and de­vel­op­ment of the off­spring,” study leader Yani Lu said in an AACR news re­lease.

While the study found a con­nec­tion be­tween a daugh­ter’s risk of cancer and her fa­ther’s age when she was born, it did not es­tab­lish a cause­and-ef­fect re­la­tion­ship.

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