THISDAY

2. Rhythm and Moods

- Fertility Women Men

But research has been finding that the body’s clock is responsibl­e for more than Disrupting our body’s natural cycles can cause problems. Studies have found there are more frequent traffic accidents and workplace injuries when we spring forward and lose an hour of sleep. Heart patients are at greater risk for myocardial infarction in the week following the Daylight Savings time shift. But even more significan­t is that science continues to discover important connection­s between a disrupted clock and chronic health issues, from diabetes to heart disease to cognitive decline.

It turns out that the same genes and biological factors that govern our internal clock are also involved in how other body systems operate -- and break down. It can be hard to determine whether a disrupted clock leads to health problems, or whether it’s the other way around.

clock interacts with and helps govern the function of other systems and affects our overall health. In fact, keeping your body’s daily cycle on an even keel may be one of the best things you can do for your overall health.

Natural factors within the body produce circadian rhythms. However, signals from the environmen­t also affect them. The main cue influencin­g circadian rhythms is daylight. This light can turn on or turn off genes that control the molecular structure of biological clocks. Changing the light-dark cycles can speed up, slow down, or reset biological clocks as well as circadian rhythms.

1. Environmen­tal disruption­s to the body’s clock Some of the best knowledge we have about the roles the biological clock plays in our health come from instances in which the cycle gets out of sync. This can happen for different reasons, and we’re just starting to understand them in greater detail. Sometimes we do things ourselves that disrupt our normal rhythms, like flying to a distant biology) that play a role.

Flying across the country on the red-eye is a prime example of how we can disrupt our own clocks, and a far more extreme example than the spring forward/ sets in, we feel disoriente­d, foggy, and sleepy at the our body clock tells us it’s one time and the outside environmen­t tells us it’s another. In fact, jet lag can be considered one type of circadian rhythm disorder. It can be treated simply be allowing the body to adjust to the new time, although it may take several days for external cues (light) to help the internal clock catch up or fall back with its new cycle.

Shift work is another example of how we can get ourselves off-cycle, and this too can develop into a circadian rhythm disorder over the long term. People who work the night shift not only have a hard time with their sleep patterns (feeling sleepy at work or experienci­ng insomnia during the day), but other systems in their bodies can also feel the effects -- and they can be chronic. It’s not been clear exactly why this connection exists, but weight gain or metabolic changes may be involved. These phenomena underline how particular behaviors or lifestyles can affect the body’s clock, but there are other factors at play, like genetics and body chemistry. lifeissues­fromwithin@yahoo.com, .Cel,

Our internal clocks also have a hand in whether we feel up or down emotionall­y. People with mood disorders like depression, bipolar disorder, and seasonal affective disorder (SAD) have altered circadian rhythms. In fact, sleep disturbanc­es, both sleeping too much and too little, are one of the key symptoms of depression and other mood disorders.

The relationsh­ip between body rhythms and mood is an intricate one, and likely has to do with how the brain chemical serotonin fluctuates in relation to the light-dark cycle and throughout the year as the days become longer and shorter. Mice bred to have problems with serotonin function also have seriously altered daily rhythms. People’s serotonin levels increase during the part of the day when there is more light available.

Understand­ing what makes biological clocks tick may lead to treatments for sleep disorders, obesity, mental health disorders, jet lag, and other health problems. It can also improve ways for individual­s to adjust to nighttime shift work. Learning more about the genes responsibl­e for circadian rhythms will also help us understand biological systems and the human body.

The timing of life , as influenced by the biological clock, affects the ability of both men and women to reproduce. Research has shown that age affects a man’s ability to have a child in a similar way to a woman.

As a woman goes from her 20s to her 30s to her 40s without having children, she’s likely to hear more and more people warn her about the risks in waiting to get pregnant.

face so much pressure to have kids as they age, but men don’t. After 35, the thinking goes, it gets harder for a woman to get pregnant, and, if she does conceive, there’s a greater risk the baby will have health problems. According to that thinking, men are mostly untouched by this process, often able to father kids until a ripe old age. Except it turns out this isn’t really true.

Researcher­s are increasing­ly arguing that men have a biological clock, too, even if most people don’t hear it ticking.

It is known that age affects a man’s ability to have a child in a similar way to a woman’s, though the timeline isn’t the same. It’s harder for older men to father children, and their offspring are more likely to have health problems, too. In fact, new research suggests that many problemati­c genetic conditions may be more closely linked to the age of the father than the mother.

But few people today seem to be aware of how a man’s age can affect a pregnancy and the health of the child. The missing knowledge could be useful for a young couple thinking about when to have kids, or a childless older couple feeling the pressure of aging. It could be a strong reason for many couples to rethink their plans about career and family, and for many people to reexamine their ideas about work, gender and their health.

Studies indicate that a man’s age can affect his fertility in three main ways. The older the father, the harder it may be for a couple to conceive a baby. Older fathers are also more likely to see pregnancie­s result in miscarriag­es. And the older age of the father can potentiall­y trigger health problems in a child, too.

Unlike women, who are born with a finite number of eggs, men continue to produce sperm throughout their life, and some can father children into their 60s and beyond – an age where women’s clocks have totally stopped ticking. George Lucas, Steve Martin and Rod Stewart all famously fathered children in their late 60’s. But for most men, testostero­ne declines as they age, which can lead to decreased libido and erectile dysfunctio­n. And as they get older, men also see a decline in the quantity and genetic quality of sperm.

The aging male, at least from a reproducti­ve perspectiv­e, is not as good when he’s older as when he’s younger.

These changes mirror similar changes in women, with a notable difference: Most seem to occur a few years later in men, and happen more gradually.

There’s a lot of disagreeme­nt about when exactly in a man’s and a woman’s life these changes occur; various studies and experts cite different ages and time periods. But many argue that, for women, fertility declines gradually in the mid- to late 30’s, and then sharply in the 40’s. For men, the change appears to happen more in their 40’s and 50’s.

One study of 2000 couples in France found that while women’s reproducti­ve capacity tends to decline around 35, men experience a similar, though more gradual, decline after the age of 40. Several studies suggest that men over the age of 35 are twice as likely to be infertile as those younger than 25. Another study of about 2,000 couples in the U.K. showed that, after controllin­g for a woman’s age and other factors, men who were 45 and older took five times longer to conceive than those who were 25 and younger.

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