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since Gilles Muller in 2008.

“I’m playing my second main draw Slam. It’s huge,” Shapovalov said. “It opens up the draw and helps players like myself have a chance.”

Shapovalov will play for a quarterfinal berth against Spanish 12th seed Pablo Carreno Busta, who ousted French qualifier Nicolas Mahut 6-3, 6-4, 6-3.

The Spaniard, who has not dropped a set, will become the first player to face four qualifiers at a Grand Slam in the Open Era (since 1967).

With US 10th seed John Isner being ousted 6-4, 6-3, 7-6 (7/5) by German 23rd seed Mischa Zverev, Carreno Busta became the top remaining seed in his half of the draw. Zverev gets US 17th seed Querrey next.

Italy’s Paolo Lorenzi, 35, became the oldest player in the Open Era to reach a Grand Slam last 16 for the first time by defeating countryman Thomas Fabbiano 6-2, 6-4, 6-4.

Lorenzi next meets South African Kevin Anderson, who beat Croatian Borna Coric 6-4, 6-3, 6-2. Anderson has won all 43 of his US Open service games and saved all 14 break points he has faced. NEW AUNT VENUS ADVANCES

Baby news from Florida turned heads as Serena Williams, a 23-time Grand Slam champion and six-time US Open winner, gave birth to a baby daughter.

She was pregnant in January when she beat older sister Venus Williams in the Australian Open final. US ninth seed Venus beat Greece’s 95th-ranked Maria Sakkari 6-3, 6-4 and said she was “super-excited.”

“To win in straight sets shows I’m playing some good tennis,” Venus said.

Wimbledon champion Garbine Muguruza needed only 62 minutes to defeat Slovakian 31st seed Magdalena Rybarikova 6-1, 6-1 and continue her best US Open run as well as take command of the fight for women’s world number one.

Only current number one Karolina Pliskova and fourth-seeded Elina Svitolina can deny Muguruza reaching the top spot for the first time.

“I’m taking every match as a final here,” Muguruza said.