China diabetes triples creating $ 3.2 billion drug market
Doctor Li Guangwei sees China’s struggle with 90 million diabetes sufferers daily. Among the standing-room-only crowd waiting outside his clinic door are patients with slurred speech, mismatched clothes and aggression.
These are the ones with low bloodsugar, a condition that can make people appear drunk and is often caused by too much of the hormone insulin, said Li, head of Fuwai Hospital’s diabetes unit. More than half of China’s diabetics have inadequate blood- glucose control, a 2011 study of 140,000 patients showed.
Prevalence of Type 2 diabetes, a disease linked to inactivity and excess calories, has more than tripled in China over the past decade, fueling 20 percent-a-year growth in drug sales and straining health services. It’s also stoking need for newer, costlier medications from Merck & Co. (MRK), Novo Nordisk A/S (NOVOB) and Sanofi that help avoid blood-sugar spikes and complications such as heart attack and stroke.
“If we can choose drugs with little or no risk to more effectively treat patients, we can stop using older drugs that raise insulin levels and can cause hypoglycemia,” said Li, using the medical term for low-blood sugar that sometimes causes his patients to become delirious and to pick fights. “It impairs brain function and there’s no way to stop it until we get the blood sugar back to normal.”
The mainstay diabetes treatment worldwide is metformin, available free in China through the government’s national health insurance program. Doctors want to augment the 50-year-old pill with newer medicines, such as Januvia from Merck, which helps to stabilize blood-sugar, according to an April 2012 paper in the journal Diabetes & Metabolism. Victoza, sold by Novo Nordisk, offers “minimum risk of hypoglycemia,” according to company- sponsored research in the Lancet in 2010.
As few as two in five diabetics in China have their blood- sugar under control, said Ji Linong, president of the Chinese Diabetes Society, potentially damaging the heart, blood vessels, kidneys, eyes and feet. That compares with the U.S., where blood-sugar is controlled in 70 percent, according to Manish Pant, director of policy and programs at the International Diabetes Federation in Brussels.
A key difference is that an average of $194 a year is spent treating each diabetes patient in China, versus more than $5,000 in developed countries such as the U.S., the IDF said. Even as China’s health-spending is forecast to almost triple to $1 trillion over the next eight years, surging rates of diabetes mean China is struggling to detect cases and provide basic care, according to Pant.
China has almost four times as many people with diabetes than the U.S., where there are 23.7 million sufferers, according to the IDF. By 2030, 40 million more will have the condition in China, where diabetes causes 173.4 billion yuan ($28 billion) a year in medical costs, the diabetes group estimates.
“China, unfortunately, has become the world’s capital for diabetes,” said Michael Rosenblatt, Merck’s chief medical officer, in an Oct. 25 interview in Shanghai. “The government is starting to pay more attention as this is the beginning of a huge problem, both health and economic.”
China’s diabetes drugs market will expand 20 percent annually to reach 20 billion yuan ($3.2 billion) by 2016, spurred by guidelines that set higher treatment standards, said Yan Shangjun, a Shanghai-based consultant with IMS Health Inc. China’s pharmaceuti- cals market overall will increase 15-to-18 percent a year to reach as much as $165 billion over the same period, the research company said in July.
Merck’s Januvia was approved for use in China in 2009 and costs 9.6 yuan ($1.50) per 100-milligram tablet, typically taken daily. Merck has applied to have the medicine added to China’s National Drug Reimbursement List, the Whitehouse Station, New Jersey-based drugmaker said in an e-mail.
It takes as long as five years for a new product to be added to the reimbursement list, McKinsey & Co. said in an August report. Addition makes it available to the masses and can bolster sales.