What is APAS?

Understanding Anti-Phospholipid Antibody Syndrome amid pregnancy

THE Mayo Clinic defines and describes APAS, or Anti-phospholipid Antibody Syndrome, as a complex autoimmune disorder in which the immune system mistakenly creates antibodies that attack tissues in the body. These antibodies can cause blood clots to form in arteries and veins.

This condition can affect various organs and systems in the body, leading to a range of symptoms and potential complications.

During pregnancy, APAS can result in miscarriage and stillbirth.

Causes:

The Mayo Clinic furthers that APAS occurs when the immune system mistakenly produces antibodies that make blood much more likely to clot. Antibodies usually protect the body against invaders, such as viruses and bacteria.

The exact cause of APAS is not fully understood, but genetics and environmental factors may play a role in triggering the immune system to produce these abnormal antibodies.

Symptoms:

The symptoms of APAS can vary widely depending on the organs and systems affected. Common symptoms may include:

- Recurrent blood clots, such as deep vein thrombosis (DVT) or pulmonary embolism (PE).

- Pregnancy complications, including recurrent miscarriages, pre-eclampsia, or fetal growth restriction.

- Neurological symptoms, such as headaches, seizures, strokes or transient ischemic attack (TIA) - Skin problems, such as rash

- Other symptoms may include chronic headaches, including migraines, cardiovascular problems, such as chest pain or heart attacks, and Low blood platelet counts (thrombocytopenia).

Management:

Treatment of APAS aims to prevent blood clots, manage symptoms, and reduce the risk of complications. Treatment strategies may include anticoagulant or antiplatelet medication, depending on the individual’s symptoms and medical history.

Pregnant individuals with APAS may require close monitoring and specialized care to prevent miscarriages and other pregnancyrelated complications.