NOW FOR GENETICALLY MODDED ANIMALS
Last year, a bull specially bred to have a dominant hornless trait, sired several offspring
COWS that can withstand hotter temperatures. Cows born without pesky horns. Pigs that never reach puberty.
A company wants to alter farm animals by adding and subtracting genetic traits in a lab. It sounds like science fiction, but Recombinetics sees opportunity for its technology in the livestock industry.
But first, it needs to convince regulators that gene-edited animals are no different than conventionally bred ones. To make the technology appealing and to ease any fears that it may be creating Franken-animals, Recombinetics isn’t starting with productivity. Instead, it’s introducing gene-edited traits as a way to ease animal suffering.
“It’s a better story to tell,” said Tammy Lee, chief executive of the St Paul, Minnesota-based company.
For instance, animal welfare advocates have long criticised the way farmers use caustic paste or hot irons to dehorn dairy cows so the animals don’t harm each other. Recombinetics snips out the gene for growing horns so the procedure is unnecessary.
Last year, a bull gene-edited by Recombinetics to have the dominant hornless trait sired several offspring. All were born hornless as expected, and are being raised at the University of California, Davis. Once the female offspring starts lactating, its milk will be tested for any abnormalities.
Another Recombinetics project: castration-free pigs.
When male piglets go through puberty, their meat can take on an unpleasant odour, something known as “boar taint.” To combat it, farmers castrate pigs, a procedure animal welfare advocates say is commonly performed without painkillers. Editing genes so that pigs never go through puberty would make castration unnecessary.
Also in development are dairy cows that could withstand higher temperatures, so the animals don’t suffer in hotter climates.
Recombinetics and others say gene-editing techniques do what traditional breeding has always done, except much faster and with the precision of “molecular scissors.”
Most US dairy cows are already bred through artificial insemination from “semen straws,” which are priced for a bull’s pedigree and traits developed through years of traditional breeding. Gene-edited traits would just be higher-priced extras, Recombinetics says. For example, the hornless trait could add $3 to $5 to the price of a semen straw that could cost around $15 (R214).
Once gene-editing is accepted by the public, farmers will be more interested in traits that step up productivity, Lee predicted. As an example, she cited pigs edited to have bigger litters.
Before food from gene-edited animals can land on dinner tables, however, Recombinetics has to overcome any public unease about the technology.
Beyond worries about “playing God,” it may be an uncomfortable reminder of how modern food production already treats animals, said Paul Thompson, a professor of agriculture at Michigan State University.
“There’s an ethical question that’s been debated for at least the last 20 years, of whether you need to change the animal or change the system,” Thompson said.
Support for gene editing will also likely depend on how the technology is used: whether it’s for animal welfare, productivity or disease resistance. In August, a Pew study found 43 percent of Americans supported genetically engineered animals for more nutritious meat.
The array of possibilities is why the Humane Society of the US supports gene-editing to end pig castrations and cow de-horning but doesn’t give the technology its blanket approval.
“If you edit for your chicken to be the size of an elephant, that’s not good,” said Josh Balk, the group’s vice-president of farm animal protection.
The image seems preposterous, but it may not be far off from what the words “gene-edited animals” conjure for many. In the science-fiction movie
earlier this year, gene-editing is used to create monsters, including a giant wolf that shoots porcupine spikes from its tail.
Some may also question the need to risk using the technology, if it really just speeds up what could be achieved with conventional breeding.
Notably, hornless dairy cows also already exist. But Recombinetics says there are so few that breeding them would compromise the valuable traits that have been carefully bred into modern dairy cows.
A challenge for Recombinetics will be coming up with gene-edited traits farmers are willing to pay for. Semex, a Canadian company, says it will take at least two years of testing before it can start selling the hornless trait for dairy cows. |