Experts hail new TB drug cure finding

Belarus doctors say 80% of patients healed in trial run replicated elsewhere

A new treatment for a drugresistant strain of tuberculosis can cure 80% of sufferers, according to a trial hailed Monday as a “game-changer” in the fight against the global killer.

Doctors in Belarus – a country with one of the highest rates of multidrug-resistant tuberculosis in the world – spent months treating patients with a new drug, bedaquiline, alongside other antibiotics.

The results, were startling: Of the 181 patients given the new drug, 168 people completed the course and 144 were totally cured.

The World Health Organisation says currently only 55% of people with multidrug-resistant tuberculosis are successfully treated.

The Belarus trial cure rate – 80% – was largely replicated in bedaquiline trials in other countries in eastern Europe, Africa and Southeast Asia, reports of which are due to be unveiled at a major tuberculosis conference later this week.

“The results from this study confirm, that newer drugs like bedaquiline can cure and are game-changers for people living with multidrug-resistant and extremely drug-resistant tuberculosis,” Paula Fujiwara, scientific director of The International Union Against Tuberculosis and Lung Disease who was not involved in the research, said.

Lead researcher Alena Skrahina, from the Republican Research and Practical Centre for Pulmonology and TB in Minsk, called the bedaquiline results “promising”.

“Generally, our study confirms the effectiveness of bedaquiline in previous clinical trials, and does not confirm the concerns about safety problems,” she said.

Tuberculosis killed at least 1.7m people in 2017, according to the WHO, making the airborne infection the world’s deadliest infectious disease.

It kills more than three times as many people as malaria every year and is responsible for the majority of HIV-Aids deaths.

Despite the huge death toll, tuberculosis receives roughly a tenth of the global research funding that goes to HIV-Aids. multidrug-resistant tuberculosis is immune to two of the most common anti-bacterial drugs used to treat the disease.

Experts believe it is spreading worldwide due to poor handling of tuberculosis cases. Unlike other global killers such as HIV, tuberculosis is curable – but currently only under a strict six-month supervised regimen involving multiple daily drug doses.